Observational studyMedicine2017
A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study.
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Sex-specific distribution of the uric acid-to-HDL cholesterol ratio and its association with arterial stiffness in a Japanese health check-up population: a cross-sectional analysis.Frontiers in endocrinology · 2026Article
- Association Between Uric Acid and Worsening Peripheral Microangiopathy in Systemic Sclerosis.Frontiers in medicine · 2021Article
- Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes.Frontiers in endocrinology · 2021Article
- Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance.Nutrients · 2020Article
- Pulse wave velocity progression over a medium-term follow-up in hypertensives: Focus on uric acid.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Vascular Aging and Disease of the Large Vessels: Role of Inflammation.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Review
- Increased serum uric acid levels are associated with digital ulcers in patients with systemic sclerosis.Rheumatology international · 2019Article
- Determinants of Vascular Age: An Epidemiological Perspective.Clinical chemistry · 2019Review
- The role of hyperuricemia on vascular endothelium dysfunction.Biomedical reports · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperuricemia has been demonstrated to be a risk factor for cardiovascular diseases. Though the association between uric acid (UA) and arterial stiffness has been investigated previously in patients with basic diseases, the predictive value of baseline UA level for arterial stiffness has not been conducted. We aimed at identifying the predictive role of UA for arterial stiffness prospectively.A longitudinal follow-up study in a routine health check-up population was performed with an average follow-up of 4.8 years. The demographic information, baseline and follow-up anthropometric parameters, arterial stiffness (pulse-wave velocity, PWV), and biomarker variables including UA have been measured and analyzed.A total of 1447 valid follow-ups were available for the final analysis. Both of the baseline and follow-up UA levels were significantly higher in the arterial stiffness groups than that in the nonarterial stiffness groups (all P values <0.001). The follow-up carotid-femoral PWV [(cf-PWV), r = 0.161, P < 0.001] was strongly correlated with baseline UA. At the follow-up cross-section, cf-PWV was also closely associated with UA (r = 0.101, P < 0.001). Logistic regressions revealed that a higher baseline UA level was an independent predictor of follow-up arterial stiffness assessed by cf-PWV [odds ratio (OR): 1.824; P = 0.046].A higher baseline level of UA is closely related to arterial stiffness and is an independent predictor of arterial stiffening.
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