ArticleOncotarget2017
Quantitative assessment of the bidirectional relationships between diabetes and depression.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- A review of the 257 meta-analyses of the differences between females and males in prevalence and risk, protective factors, and treatment outcomes for mental disorder.BMC psychiatry · 2025Pooled it
- The bidirectional longitudinal association between depressive symptoms and HbADiabetic medicine : a journal of the British Diabetic Association · 2022Pooled it
- Trial
- Effect of a collaborative care model on anxiety symptoms among patients with depression and diabetes in India: The INDEPENDENT randomized clinical trial.General hospital psychiatryTrial
- Access to a Newly Adapted Diabetes-Specific Multimodal Cross-Sectoral and Interdisciplinary Psychotherapeutic Care Option for a High-Risk Group of Patients With Diabetes Mellitus and Distress: Protocol for the minDBe Pilot Study.JMIR research protocols · 2025Article
- The role of continuous glucose monitoring (CGM) in psychiatric symptom management.CNS spectrums · 2025Review
- Longitudinal associations of depression and diabetes with Alzheimer's disease and related dementias risk among American Indian and Alaska Native peoples.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Beyond association: Examining overweight as a mediator in the link between depression and diabetes.World journal of diabetes · 2025Article
- Prevalence and Risk Factors of Type 2 Diabetes Mellitus among Depression Inpatients from 2005 to 2018 in Beijing, China.Health data science · 2025Article
- The Interconnected Complexity of Diabetes and Depression.Diabetes spectrum : a publication of the American Diabetes Association · 2025Article
- Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration.Biological research · 2024Article
- Gender differences in the relationship between depressive symptoms and diabetes associated with cognitive-affective symptoms.BJPsych open · 2024Article
- Association between dietary patterns and depression symptoms among adults with or without diabetes in Qatar: a population-based study.BMC public health · 2024Article
- Emerging global interest: Unraveling the link between diabetes mellitus and depression.World journal of psychiatry · 2024Article
- Higher IL-6 and IL-4 plasma levels in depressed elderly women are influenced by diabetes mellitus.Trends in psychiatry and psychotherapy · 2024Article
- Article
- A personalized intervention to prevent depression in primary care based on risk predictive algorithms and decision support systems: protocol of the e-predictD study.Frontiers in psychiatry · 2023Article
- The Obesity Effect of Arizona's State Immigration Law Among Hispanic Adolescents.Journal of immigrant and minority health · 2022Article
- Article
- The association between diabetes mellitus and incidence of depressive episodes is different based on sex: insights from ELSA-Brasil.Therapeutic advances in endocrinology and metabolism · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes and depression impose an enormous public health burden and the present study aimed to assess quantitatively the bidirectional relationships between the two disorders. We searched databases for eligible articles published until October 2016. A total of 51 studies were finally included in the present bidirectional meta-analysis, among which, 32 studies were about the direction of depression leading to diabetes, and 24 studies about the direction of diabetes leading to depression. Pooled results of the 32 eligible studies covering 1274337 subjects showed that depression patients were at higher risk for diabetes (odds ratio (OR) = 1.34, 95% confidence intervals (CI) = [1.23, 1.46]) than non-depressive subjects. Further gender-subgroup analysis found that the strength of this relationship was stronger in men (OR = 1.63, 95%CI = [1.48, 1.78]) than in women (OR = 1.29, 95%CI = [1.07, 1.51]). For the direction of diabetes leading to depression, pooled data of 24 articles containing 329658 subjects showed that patients with diabetes were at higher risk for diabetes (OR = 1.28, 95%CI = [1.15, 1.42]) than non-diabetic subjects. The available data supports that the relationships between diabetes and depression are bidirectional and the overall strengths are similar in both directions. More mechanistic studies are encouraged to explore the molecular mechanisms underlying the relationships between the two diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.