Observational studyOncotarget2017
Time trends in the prevalence and epidemiological characteristics of neural tube defects in Liaoning Province, China, 2006-2015: A population-based study.
Observational study in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Perinatal prevalence of birth defects in the Mainland of China, 2000-2021: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2024Pooled it
- Global prevalence of congenital anencephaly: a comprehensive systematic review and meta-analysis.Reproductive health · 2022Pooled it
- Association of premarital medical check-ups and folic acid knowledge, attitudes, and practices with the occurrence of neural tube defects in Guangxi, China (2009-2023).Journal of global health · 2026Article
- The burden of neural tube defects in Southern Ethiopia: trends, hotspots, and public health implications.PeerJ · 2026Article
- Study on the relationship between genetic polymorphism of reductive folic acid carrier and the risk of neural tube defects.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Secular trends and age-period-cohort effect on adverse perinatal outcomes in Hubei, China (2011-2019).Scientific reports · 2022Article
- Association between maternal exposure to PMEnvironmental science and pollution research international · 2022Article
- Maternal Exposure to Sulfur Dioxide and Risk of Omphalocele in Liaoning Province, China: A Population-Based Case-Control Study.Frontiers in public health · 2022Article
- Maternal exposure to ambient levels of sulfur dioxide and risk of neural tube defects in 14 cities in Liaoning province, China: a population-based case-control study.Journal of exposure science & environmental epidemiology · 2021Article
- Maternal exposure to ambient SOEnvironmental science and pollution research international · 2021Article
- Observational
- Epidemiology and determinant factors of neural tube defect: Narrative review.Surgical neurology international · 2020Review
- Assessment of the development of assisted reproductive technology in Liaoning province of China, from 2012 to 2016.BMC health services research · 2018Article
- Prevalence and trend of isolated and complicated congenital hydrocephalus and preventive effect of folic acid in northern China, 2005-2015.Metabolic brain disease · 2018Article
- The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the time trends in the prevalence of neural tube defects and all their subtypes as well as to identify the epidemiological characteristics of these malformations documented in the Liaoning Province of northeast China from 2006 to 2015. This was a population-based observational study using data from 3,248,954 live births as well as from 6217 cases of neural tube defects, 1,600 cases of anencephaly, 2,029 cases of spina bifida, 404 cases of encephalocele, and 3,008 cases of congenital hydrocephalus from 14 cities in Liaoning Province from 2006 to 2015. All analyses were conducted using SPSS software. During the observational period, the prevalence of neural tube defects, anencephaly, spina bifida, encephalocele, and congenital hydrocephalus was 19.1, 4.9, 6.2, 1.2, and 9.3 per 10,000 live births, respectively. Significantly decreasing trends were observed in the prevalence of all these malformations except for encephalocele. Notably, relatively higher prevalence rates were found in isolated compared with non-isolated malformations, with significant differences in selected characteristics (e.g., prognosis status, gestational age, and birth weight) between isolated and non-isolated cases of these malformations. The prevalence of neural tube defects showed a downward trend in Liaoning Province from 2006 to 2015. However, more attention should be focused on non-isolated cases in the future because of the severe clinical manifestations. Future prevention efforts should be strengthened to reduce the risk of these malformations, especially the non-isolated subtype, in areas with high prevalence.
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