ArticleJournal of clinical laboratory analysis2017
Serum bilirubin and the risk of rheumatoid arthritis.
Article in Journal of clinical laboratory analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The role of bilirubin as a biomarker of rheumatic diseases: a systematic review and meta-analysis.Frontiers in immunology · 2024Pooled it
- Relationship between bilirubin and systemic lupus erythematosus: A systematic review and meta-analysis.Immunity, inflammation and disease · 2023Pooled it
- Long-term postdischarge immunonutrition management in elective colorectal cancer surgery patients an interim analysis of a Chinese multicenter randomised controlled trial.Metabolism open · 2026Article
- An assessment of an antioxidative status in patients with multiple sclerosis using standard biochemical analyses.Journal of medical biochemistry · 2025Article
- Association of UCMA With Cartilage Pathogenesis and Inflammation in Patients With Rheumatoid Arthritis: A Novel Biomarker.Journal of clinical laboratory analysis · 2025Article
- A machine learning algorithm to predict treatment effectiveness for Kawasaki disease in China: a retrospective model development and validation study.Frontiers in immunology · 2025Article
- Integrative multi-omic profiling in blood reveals distinct immune and metabolic signatures between ACPA-negative and ACPA-positive rheumatoid arthritis.Frontiers in immunology · 2025Article
- Causal inference between serum bilirubin levels and juvenile idiopathic arthritis-associated uveitis: A bidirectional Mendelian randomization study.Health science reports · 2024Article
- Metabolic Effects of Anti-TNF-α Treatment in Rheumatoid Arthritis.Diseases (Basel, Switzerland) · 2023Article
- Amelioration of Rheumatoid Arthritis byMedicina (Kaunas, Lithuania) · 2023Article
- Serum bilirubin levels in primary Sjögren's syndrome: an association with interstitial lung disease.BMC pulmonary medicine · 2023Article
- Absent in melanoma 2 (AIM2) in rheumatoid arthritis: novel molecular insights and implications.Cellular & molecular biology letters · 2022Review
- The mildly decreased preoperative bilirubin level is a risk factor for periprosthetic joint infection after total hip and knee arthroplasty.Arthroplasty (London, England) · 2021Article
- Hyperbilirubinemia Maintained by Chronic Supplementation of Unconjugated Bilirubin Improves the Clinical Course of Experimental Autoimmune Arthritis.International journal of molecular sciences · 2021Article
- Systematic identification of genetic systems associated with phenotypes in patients with rare genomic copy number variations.Human genetics · 2021Article
- Decreased Bilirubin is Associated With Disease Activity of Primary Sjögren's Syndrome.Archives of rheumatology · 2020Article
- Clinical significance of serum bilirubin in primary Sjögren syndrome patients.Journal of clinical laboratory analysis · 2020Article
- Heme-Derived Metabolic Signals Dictate Immune Responses.Frontiers in immunology · 2020Review
- Heme Catabolic Pathway in Inflammation and Immune Disorders.Frontiers in pharmacology · 2019Review
- Serum bilirubin and the risk of rheumatoid arthritis.Journal of clinical laboratory analysis · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxidative stress and immune imbalance play an important role in the pathogenesis of rheumatoid arthritis (RA). Bilirubin is a powerful antioxidant and also regarded as immunomodulator. Increased evidence shows that bilirubin should be a protective factor for autoimmune disease. However, the relationship between bilirubin and RA remain unclear.
methodsWe analyzed serum bilirubin levels and other laboratory and clinical data in 130 RA patients (35 patients without any complications), 81 osteoarthritis (OA) patients and 96 healthy controls.
resultsBinary logistic regression adjusted by age and gender revealed that the levels of serum total, indirect bilirubin were significantly lower in RA patients, when compared with healthy controls (P=.015, OR=0.767, 95% CI=0.619-0.951; P=.010, OR=0.664, 95% CI=0.487-0.906, respectively) or OA patients (P=.000, OR=0.763, 95% CI=0.661-0.882; P=.000, OR=0.656, 95% CI=0.532-0.808, respectively). A reduced trend of levels of bilirubin has been detected along with increased disease activity, despite with no significance (P>.05). Spearman rank test further demonstrated that IgG and ESR were negative associated with total, indirect bilirubin, and albumin, prealbumin, APOA, HDL-C were positively associated with bilirubin.
conclusionsIn conclusion, the levels of serum bilirubins were decreased in RA, and decreased levels could be associated with IgG, albumin and inflammatory marker ESR.
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