ArticleThe Journal of comparative neurology2017
A central mesencephalic reticular formation projection to medial rectus motoneurons supplying singly and multiply innervated extraocular muscle fibers.
Article in The Journal of comparative neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Parallel cholinergic circuit in oculomotor nucleus to control eye movements and REM sleep.Nature communications · 2026Article
- Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque.eLife · 2026Article
- Neural Innervation of Cyclovertical Extraocular Muscles During Asymmetric Vertical Vergence.Investigative ophthalmology & visual science · 2026Article
- Precerebellar paramedian tract cell groups connections: I. Oculomotor internuclear projections.Brain structure & function · 2025Article
- Neural Control of Vergence and Ocular Accommodation.Annual review of vision science · 2025Review
- A Pilot Study to Improve Cognitive Performance and Pupil Responses in Mild Cognitive Impaired Patients Using Gaze-Controlled Gaming.Vision (Basel, Switzerland) · 2024Article
- Time-on-task effects on human pupillary and saccadic metrics after theta burst transcranial magnetic stimulation over the frontal eye field.IBRO neuroscience reports · 2023Article
- Brainstem sources of input to the central mesencephalic reticular formation in the macaque.Experimental brain research · 2023Article
- Investigation of Selective Innervation of Extraocular Muscle Compartments.Investigative ophthalmology & visual science · 2023Article
- Emerging order of anomalous eye movements with progressive drowsiness.Journal of vision · 2023Article
- Is the central mesencephalic reticular formation a purely horizontal gaze center?Brain structure & function · 2022Article
- Pupillary responses to differences in luminance, color and set size.Experimental brain research · 2022Article
- A Novel Tectal/Pretectal Population of Premotor Lens Accommodation Neurons.Investigative ophthalmology & visual science · 2022Article
- Extraocular Motoneurons and Neurotrophism.Advances in neurobiology · 2022Article
- MIF versus SIF Motoneurons, What Are Their Respective Contribution in the Oculomotor Medial Rectus Pool?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cerebellar projections to the macaque midbrain tegmentum: Possible near response connections.Visual neuroscience · 2021Article
- Neural control of rapid binocular eye movements: Saccade-vergence burst neurons.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Is Primate Lens Accommodation Unilaterally or Bilaterally Controlled?Investigative ophthalmology & visual science · 2020Article
- Mouse Extraocular Muscles and the Musculotopic Organization of Their Innervation.Anatomical record (Hoboken, N.J. : 2007) · 2019Article
- Central mesencephalic reticular formation control of the near response: lens accommodation circuits.Journal of neurophysiology · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We recently demonstrated a bilateral projection to the supraoculomotor area from the central mesencephalic reticular formation (cMRF), a region implicated in horizontal gaze changes. C-group motoneurons, which supply multiply innervated fibers in the medial rectus muscle, are located within the primate supraoculomotor area, but their inputs and function are poorly understood. Here, we tested whether C-group motoneurons in Macaca fascicularis monkeys receive a direct cMRF input by injecting this portion of the reticular formation with anterograde tracers in combination with injection of retrograde tracer into the medial rectus muscle. The results indicate that the cMRF provides a dense, bilateral projection to the region of the medial rectus C-group motoneurons. Numerous close associations between labeled terminals and each multiply innervated fiber motoneuron were present. Within the oculomotor nucleus, a much sparser ipsilateral projection onto some of the A- and B- group medial rectus motoneurons that supply singly innervated fibers was observed. Ultrastructural analysis demonstrated a direct synaptic linkage between anterogradely labeled reticular terminals and retrogradely labeled medial rectus motoneurons in all three groups. These findings reinforce the notion that the cMRF is a critical hub for oculomotility by proving that it contains premotor neurons supplying horizontal extraocular muscle motoneurons. The differences between the cMRF input patterns for C-group versus A- and B-group motoneurons suggest the C-group motoneurons serve a different oculomotor role than the others. The similar patterns of cMRF input to C-group motoneurons and preganglionic Edinger-Westphal motoneurons suggest that medial rectus C-group motoneurons may play a role in accommodation-related vergence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.