ArticleThe Journal of comparative neurology2017
Segregated fronto-cortical and midbrain connections in the mouse and their relation to approach and avoidance orienting behaviors.
Article in The Journal of comparative neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- M2 Cortex Circuitry and Sensory-Induced Behavioral Alterations in Huntington's Disease: Role of Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Uncovering Statistical Links Between Gene Expression and Structural Connectivity Patterns in the Mouse Brain.Neuroinformatics · 2021Article
- Organization of the inputs and outputs of the mouse superior colliculus.Nature communications · 2021Article
- A specialized reciprocal connectivity suggests a link between the mechanisms by which the superior colliculus and parabigeminal nucleus produce defensive behaviors in rodents.Scientific reports · 2020Article
- Article
- Spatial representations in the superior colliculus are modulated by competition among targets.Neuroscience · 2019Article
- Subtypes of GABAergic cells in the inferior colliculus.Hearing research · 2019Review
- Integration of visual and whisker signals in rat superior colliculus.Scientific reports · 2018Article
- Sensory representation of an auditory cued tactile stimulus in the posterior parietal cortex of the mouse.Scientific reports · 2018Article
- GABAergic and non-GABAergic projections to the superior colliculus from the auditory brainstem.Brain structure & function · 2018Article
- Stimulation of the Nigrotectal Pathway at the Level of the Superior Colliculus Reduces Threat Recognition and Causes a Shift From Avoidance to Approach Behavior.Frontiers in neural circuits · 2018Article
- Segregated fronto-cortical and midbrain connections in the mouse and their relation to approach and avoidance orienting behaviors.The Journal of comparative neurology · 2017Article
- Whole-brain mapping of efferent projections of the anterior cingulate cortex in adult male mice.Molecular painArticle
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The orchestration of orienting behaviors requires the interaction of many cortical and subcortical areas, for example the superior colliculus (SC), as well as prefrontal areas responsible for top-down control. Orienting involves different behaviors, such as approach and avoidance. In the rat, these behaviors are at least partially mapped onto different SC subdomains, the lateral (SCl) and medial (SCm), respectively. To delineate the circuitry involved in the two types of orienting behavior in mice, we injected retrograde tracer into the intermediate and deep layers of the SCm and SCl, and thereby determined the main input structures to these subdomains. Overall the SCm receives larger numbers of afferents compared to the SCl. The prefrontal cingulate area (Cg), visual, oculomotor, and auditory areas provide strong input to the SCm, while prefrontal motor area 2 (M2), and somatosensory areas provide strong input to the SCl. The prefrontal areas Cg and M2 in turn connect to different cortical and subcortical areas, as determined by anterograde tract tracing. Even though connectivity pattern often overlap, our labeling approaches identified segregated neural circuits involving SCm, Cg, secondary visual cortices, auditory areas, and the dysgranular retrospenial cortex likely to be involved in avoidance behaviors. Conversely, SCl, M2, somatosensory cortex, and the granular retrospenial cortex comprise a network likely involved in approach/appetitive behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.