Evidence map›Paper›PMID 28177301›Full record

ArticlePhysics in medicine and biology2017

Tracking short-term biodistribution and long-term clearance of SPIO tracers in magnetic particle imaging.

Paul Keselman, Elaine Y Yu, Xinyi Y Zhou, Patrick W Goodwill, Prashant Chandrasekharan, R Matthew Ferguson, Amit P Khandhar, Scott J Kemp, Kannan M Krishnan, Bo Zheng and 1 more

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Stimuli-Responsive Materials for Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  7. Review
  8. On the partial volume effect in magnetic particle imaging.Physics in medicine and biology · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Elucidating Iron Metabolism through Molecular Imaging.Current issues in molecular biology · 2024
    Review
  15. Article
  16. Theranostics · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Paul KeselmanDepartment of Bioengineering, University of California Berkeley, Berkeley CA 94720, United States of America.
Elaine Y YuDepartment of Bioengineering, University of California Berkeley, Berkeley CA 94720, United States of America.
Xinyi Y ZhouDepartment of Bioengineering, University of California Berkeley, Berkeley CA 94720, United States of America.
Patrick W GoodwillMagnetic Insight Inc., Newark CA 94560, United States of America.
Prashant ChandrasekharanDepartment of Bioengineering, University of California Berkeley, Berkeley CA 94720, United States of America.
R Matthew FergusonLodeSpin Labs, PO Box 95632, Seattle WA 98145, United States of America.
Amit P KhandharLodeSpin Labs, PO Box 95632, Seattle WA 98145, United States of America.
Scott J KempLodeSpin Labs, PO Box 95632, Seattle WA 98145, United States of America.
Kannan M KrishnanLodeSpin Labs, PO Box 95632, Seattle WA 98145, United States of America.
Bo ZhengDepartment of Bioengineering, University of California Berkeley, Berkeley CA 94720, United States of America.
Steven M ConollyDepartment of Bioengineering, University of California Berkeley, Berkeley CA 94720, United States of America.

Funding

Pre-clinical quantitation of ovarian cancer tumor burden using Magnetic Particle Imaging and non-dilutive cell labelingR01EB019458 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI BELL, CALEB B., CONOLLY, STEVEN M · 2015 to 2018
$1.9M
Magnetic Particle Imaging Angiography for Chronic Kidney Disease PatientsR01EB013689 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONOLLY, STEVEN M · 2011 to 2014
$1.6M
Magnetic Particle Imaging (MPI) for Functional Brain Imaging in HumansR24MH106053 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CONOLLY, STEVEN M, GRISWOLD, MARK · 2014 to 2016
$1.5M
Monodispersed magnetic nanoparticles for improved diagnostic imaging. Phase II: SR42EB013520 · NIBIB · LODESPIN LABS, LLC · PI KRISHNAN, KANNAN MANJAPRA · 2013 to 2014
$1.1M
NIBIB NIH HHS R01 EB013689NIBIB NIH HHS R01 EB019458NIBIB NIH HHS R42 EB013520NIMH NIH HHS R24 MH106053
6 · The paper itself

Abstract

Magnetic particle imaging (MPI) is an emerging tracer-based medical imaging modality that images non-radioactive, kidney-safe superparamagnetic iron oxide (SPIO) tracers. MPI offers quantitative, high-contrast and high-SNR images, so MPI has exceptional promise for applications such as cell tracking, angiography, brain perfusion, cancer detection, traumatic brain injury and pulmonary imaging. In assessing MPI's utility for applications mentioned above, it is important to be able to assess tracer short-term biodistribution as well as long-term clearance from the body. Here, we describe the biodistribution and clearance for two commonly used tracers in MPI: Ferucarbotran (Meito Sangyo Co., Japan) and LS-oo8 (LodeSpin Labs, Seattle, WA). We successfully demonstrate that 3D MPI is able to quantitatively assess short-term biodistribution, as well as long-term tracking and clearance of these tracers in vivo.

Indexed as

AnimalsFemaleImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetite NanoparticlesMetabolic Clearance RateMolecular ImagingOrgan SpecificityRatsRats, Inbred F344Tissue DistributionMagnetite Nanoparticles

Identifiers

PMID28177301
PMCPMC5739049

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.