ArticleeLife2017
Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 90 citations in OpenAlex.
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- Shared competence forms the basis of gill arch and paired fin serial homology.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Postnatal development and form-function relationships of the vocal folds in California mice (American journal of physiology. Cell physiology · 2026Article
- Microevolutionary divergence and plasticity of laryngeal shape in the house mouse (American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Developmental trajectories in laryngeal anatomy of California mice (Royal Society open science · 2025Article
- The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture.Nature communications · 2025Article
- The domestication of the wolf larynx-testing the neural crest connection.Royal Society open science · 2025Article
- Vocal recognition of partners by female prairie voles.iScience · 2025Article
- Superstable lipid vacuoles endow cartilage with its shape and biomechanics.Science (New York, N.Y.) · 2025Article
- Pleiotropic function of Dlx5/6 in the development of mammalian vocal and auditory organs.PloS one · 2025Article
- Co-option of neck muscles supported the vertebrate water-to-land transition.Nature communications · 2024Article
- Multiple embryonic sources converge to form the pectoral girdle skeleton in zebrafish.Nature communications · 2024Article
- Vocal recognition of partners by female prairie voles.bioRxiv : the preprint server for biology · 2024Article
- Histology Atlas of the Developing Mouse Respiratory System From Prenatal Day 9.0 Through Postnatal Day 30.Toxicologic pathology · 2024Review
- The domestication of the larynx: The neural crest connection.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Postnatal changes in thyroid cartilage shape and cartilage matrix composition are not synchronized in Mus musculus.Journal of anatomy · 2024Article
- Article
- The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development.Journal of anatomy · 2024Article
- Musculoskeletal morphogenesis supports the convergent evolution of bat laryngeal echolocation.Proceedings. Biological sciences · 2024Article
- Disruption of BMP4 signaling is associated with laryngeal birth defects in a mouse model.Developmental biology · 2023Article
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
Acoustic communication is fundamental to social interactions among animals, including humans. In fact, deficits in voice impair the quality of life for a large and diverse population of patients. Understanding the molecular genetic mechanisms of development and function in the vocal apparatus is thus an important challenge with relevance both to the basic biology of animal communication and to biomedicine. However, surprisingly little is known about the developmental biology of the mammalian larynx. Here, we used genetic fate mapping to chart the embryological origins of the tissues in the mouse larynx, and we describe the developmental etiology of laryngeal defects in mice with disruptions in cilia-mediated Hedgehog signaling. In addition, we show that mild laryngeal defects correlate with changes in the acoustic structure of vocalizations. Together, these data provide key new insights into the molecular genetics of form and function in the mammalian vocal apparatus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.