Evidence map›Paper›PMID 28177174›Full record

ArticlePaediatric anaesthesia2017

A case-controlled comparison of postoperative analgesic dosing between girls with Rett syndrome and girls with and without developmental disability undergoing spinal fusion surgery.

Chantel C Barney, Alyssa M Merbler, Kelsey Quest, Breanne J Byiers, George L Wilcox, Scott Schwantes, Samuel A Roiko, Timothy Feyma, Arthur Beisang, Frank J Symons

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatric anaesthesia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05488938 (An Intensive Anti-Scoliosis Postural Intervention Supported by an Application for Individuals With Rett Syndrome), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05488938 nacompletednot on this mapstarted 2021, after this paper: background citation

An Intensive Anti-Scoliosis Postural Intervention Supported by an Application for Individuals With Rett Syndrome

TypeinterventionalSponsorAriel UniversityRan2021 to 2023Enrolled20ConditionsRett SyndromeArmsRehabilitative Intervention
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Chantel C BarneyGillette Children's Specialty Healthcare, St. Paul, MN, USA.
Alyssa M MerblerDepartment of Educational Psychology, University of Minnesota, Minneapolis, MN, USA.
Kelsey QuestDepartment of Educational Psychology, University of Minnesota, Minneapolis, MN, USA.
Breanne J ByiersDepartment of Educational Psychology, University of Minnesota, Minneapolis, MN, USA.
George L WilcoxDepartment of Neuroscience, Pharmacology and Dermatology, University of Minnesota Medical School, Minneapolis, MN, USA.
Scott SchwantesGillette Children's Specialty Healthcare, St. Paul, MN, USA.
Samuel A RoikoGillette Children's Specialty Healthcare, St. Paul, MN, USA.
Timothy FeymaRett Syndrome Clinic, Gillette Children's Specialty Healthcare, St. Paul, MN, USA.
Arthur BeisangRett Syndrome Clinic, Gillette Children's Specialty Healthcare, St. Paul, MN, USA.
Frank J SymonsDepartment of Educational Psychology, University of Minnesota, Minneapolis, MN, USA.
Gillette Children's Specialty Healthcare · USUniversity of Minnesota · USMinnesota Department of Education · USUniversity of Minnesota Medical Center · US

Funding

Sensory Mechanisms and Self-InjuryR01HD044763 · NICHD · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FRANK J SYMONS · 2004 to 2026
$7.2M
Intrathecal Baclofen and Pain Outcomes in Cerebral PalsyR01HD073126 · NICHD · UNIVERSITY OF MINNESOTA · PI SYMONS, FRANK J · 2013 to 2017
$2.4M
Self-injury: Pain and Stress MechanismsK02HD047201 · NICHD · UNIVERSITY OF MINNESOTA · PI SYMONS, FRANK J · 2006 to 2010
$554k
NICHD NIH HHS K02 HD047201NICHD NIH HHS R01 HD044763NICHD NIH HHS R01 HD073126
6 · The paper itself

Abstract

backgroundRett syndrome is associated with severe motor and communicative impairment making optimal postoperative pain management a challenge. There are case reports documenting reduced postoperative analgesic requirement in Rett syndrome.

aimThe goal of this preliminary investigation was to compare postoperative analgesic management among a sample of girls with Rett syndrome compared to girls with and without developmental disability undergoing spinal fusion surgery.

methodThe medical records of eight girls with Rett syndrome (mean age = 13.2 years, sd = 1.9), eight girls with developmental disability (cerebral palsy; mean age = 13.1 years, sd = 2.0), and eight girls without developmental disability (adolescent idiopathic scoliosis; mean age = 13.4, sd = 1.8) were reviewed. Data related to demographics, medications, and route of drug administration were recorded.

resultsGirls with Rett syndrome received significantly fewer morphine equivalent opioids postoperatively (M = 0.26 mg·kg

conclusionThis study highlights possible discrepancies in postoperative pain management specific to girls with Rett syndrome and suggests further investigation is warranted to determine best practice for postoperative analgesic management for this vulnerable patient population.

Indexed as

Spinal FusionAdolescentAnalgesia, Patient-ControlledAnalgesics, OpioidCase-Control StudiesDevelopmental DisabilitiesDose-Response Relationship, DrugFemaleHumansPostoperative PainRett SyndromeAnalgesics, Opioidadolescentcommunication disordersopioidpainpediatricscoliosis

Identifiers

PMID28177174
PMCPMC5319894
OpenAlexW2587097521

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.