Evidence map›Paper›PMID 28177125›Full record

ArticleJournal of periodontal research2017

Association of oral microbiome with type 2 diabetes risk.

J Long, Q Cai, M Steinwandel, M K Hargreaves, S R Bordenstein, W J Blot, W Zheng, X O Shu

Abstract read
In one paragraph

Article in Journal of periodontal research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 3 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 3 syntheses or guidelines pooled it, 199 citations in OpenAlex.

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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

J LongDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Q CaiDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
M SteinwandelInternational Epidemiology Institute, Rockville, MD, USA.
M K HargreavesDepartment of Internal Medicine, Meharry Medical College, Nashville, TN, USA.
S R BordensteinDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
W J BlotDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
W ZhengDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
X O ShuDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University Medical Center · USInternational Epidemiology Institute · USMeharry Medical College · USVanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Maureen Sanderson · 2017 to 2026
$48.2M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Translational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2011 to 2025
$18.8M
VANTAGE:Consolidation to create the Vanderbilt Technologies for Advanced GenomicsG20RR030956 · NCRR · VANDERBILT UNIVERSITY · PI PIETENPOL, JENNIFER A · 2010 to 2010
$8.7M
Oral Microbiome and Lung Cancer RiskR01CA207466 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CAI, QIUYIN, ROSENBERG, LYNN · 2016 to 2019
$2.7M
NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA207466NCI NIH HHS U54 CA163069NCRR NIH HHS G20 RR030956NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe oral microbiome may help to maintain systemic health, including how it affects blood glucose levels; however, direct evidence linking the oral microbiome with diabetes is lacking. MATERIAL AND

methodsWe compared the oral microbiome profiles of 98 participants with incident diabetes, 99 obese non-diabetics and 97 normal weight non-diabetics, via deep sequencing of the 16S rRNA gene.

resultsWe found that the phylum Actinobacteria was present significantly less abundant among patients with diabetes than among the controls (p = 3.9 × 10

conclusionOur study revealed that multiple bacteria taxa in the phylum Actinobacteria are associated with the risk of type 2 diabetes. Some are also associated with the prevalence of obesity, suggesting that the oral microbiome may play an important role in diabetes etiology.

Indexed as

MicrobiotaActinobacteriaActinomycesAdultAgedBifidobacteriumCase-Control StudiesCorynebacteriumDiabetes Mellitus, Type 2FemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedMouthObesityRNA, Ribosomal, 16Sdiabetesnext-generation sequencingoral microbiome

Identifiers

PMID28177125
PMCPMC5403709
OpenAlexW2586217118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.