ArticleSchizophrenia bulletin2017
Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Childhood Trauma and Neurocognition in Adults With Psychotic Disorders: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2019Pooled it
- On the Same Wavelength: The Relationship between Neural Synchrony and Cognitive Ability during Movie Watching in Late Childhood and Early Adolescence.Developmental neuroscience · 2026Article
- Evaluating psychosis-specific effects of trauma exposure in early-onset and adult-onset psychosis.Psychological medicine · 2026Article
- Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors.Psychological medicine · 2025Article
- Studying the relationship between intelligence quotient and schizophrenia polygenic scores in a family design with first-episode psychosis population.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Familiality of the Intelligence Quotient in First Episode Psychosis: Is the Degree of Family Resemblance Associated With Different Profiles?Schizophrenia bulletin · 2024Article
- Independent effects of early life adversity on social cognitive function in patients with schizophrenia.Frontiers in psychiatry · 2024Article
- The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.Social psychiatry and psychiatric epidemiology · 2023Article
- Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls.Schizophrenia research. Cognition · 2023Article
- ContextPsychological medicine · 2023Article
- Environmental Risk Factors and Cognitive Outcomes in Psychosis: Pre-, Perinatal, and Early Life Adversity.Current topics in behavioral neurosciences · 2023Review
- Association of childhood trauma with cognitive domains in adult patients with mental disorders and in non-clinical populations: a systematic review.Frontiers in psychology · 2023Review
- Childhood Maltreatment, Educational Attainment, and IQ: Findings From a Multicentric Case-control Study of First-episode Psychosis (EU-GEI).Schizophrenia bulletin · 2022Article
- Exploring the Interplay Between Adversity, Neurocognition, Social Cognition, and Functional Outcome in People With Psychosis: A Narrative Review.Frontiers in psychiatry · 2021Review
- Does childhood trauma influence cognitive functioning in schizophrenia? The association of childhood trauma and cognition in schizophrenia spectrum disorders.Schizophrenia research. Cognition · 2020Article
- The Impact of Childhood Adversity on Cognitive Development in Schizophrenia.Schizophrenia bulletin · 2020Article
- The role of childhood trauma in cognitive performance in schizophrenia and bipolar disorder - A systematic review.Schizophrenia research. Cognition · 2019Review
- Childhood Trauma Associated White Matter Abnormalities in First-Episode Schizophrenia.Schizophrenia bulletin · 2019Article
- Glucocorticoid receptor alpha translational isoforms as mediators of early adversities and negative emotional states.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
- White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?Frontiers in psychiatry · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research suggests that childhood trauma is associated with cognitive alterations, but it is not known whether the cognitive alterations observed in patients with psychotic disorder, and their relatives, is trauma-related. Patients with a schizophrenia-spectrum diagnosis (n = 1119), siblings of patients (n = 1059) and healthy comparison subjects (HCS; n = 586) were interviewed 3 times over a period of 6 years. Repeated measures of IQ were analyzed as a function of childhood trauma and group, controlling for confounders. There were significant differences in the impact of childhood trauma on IQ across the 3 groups. Exposure in HCS was associated with a nearly 5-point reduction in IQ (-4.85; 95% confidence interval [CI]: -7.98 to -1.73, P = .002), a lesser reduction in siblings (-2.58; 95% CI: -4.69 to -0.46, P = .017) and no significant reduction in patients (-0.84; 95% CI: -2.78 to 1.10, P = .398). One-fourth of the sibling-control difference in IQ was reducible to childhood trauma, whereas for patients this was only 5%. Over the 6-year follow-up, those with trauma exposure showed significantly less learning effects with repeated cognitive assessments (b = 1.36, 95% CI: 0.80‒1.92, P < .001) than the nonexposed (b = 2.31, 95% CI: 1.92‒2.71, P < .001; P interaction = .001). Although childhood trauma impacts cognitive ability and learning in non-ill people at low and high genetic risk, its effect on the observed cognitive alterations in psychotic disorder may be minor. Twin and family studies on cognitive alterations in psychotic disorder need to take into account the differential impact of trauma on cognition across ill and non-ill, at risk groups.
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