ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
Prevalence of and factors associated with antipsychotic polypharmacy in patients with serious mental illness: Findings from a cross-sectional study in an upper-middle-income country.
Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Socioenvironmental determinants of polypharmacy in mental health disorders: a systematic review.BMC public health · 2026Pooled it
- Antipsychotic Polypharmacy Among Patients With Schizophrenia in Africa: A Systematic Review and Meta-Analysis.The international journal of neuropsychopharmacology · 2021Pooled it
- Psychiatric polypharmacy in adult patients at the only referral psychiatric institute in Botswana: A cross-sectional study.PloS one · 2026Article
- Complex Psychotropic Polypharmacy in Soweto-based community psychiatry clinics.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025Article
- Factors associated with potential drug-drug interactions in psychiatric inpatients.European journal of hospital pharmacy : science and practice · 2024Article
- Nationwide study on antipsychotic polypharmacy among forensic psychiatric patients.International journal of circumpolar health · 2023Article
- Article
- The experience of intergenerational interactions and their influence on the mental health of older people living in residential care.PloS one · 2023Article
- Article
- Prescribing patterns of long-acting injectable antipsychotics in a community setting in South Africa.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2022Article
- Current use of anticholinergic medications in a large naturalistic sample of psychiatric patients.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Defining polypharmacy: in search of a more comprehensive determination method applied in a tertiary psychiatric hospital.Therapeutic advances in psychopharmacology · 2021Article
- The More, the Merrier…? Antipsychotic Polypharmacy Treatment Strategies in Schizophrenia From a Pharmacology Perspective.Frontiers in psychiatry · 2021Article
- Factors associated with high-dose antipsychotic prescriptions in outpatients with schizophrenia: An analysis of claims data from a Japanese prefecture.Neuropsychopharmacology reports · 2020Article
- Prevalence and sort of pharmacokinetic drug-drug interactions in hospitalized psychiatric patients.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Meaning and Management of Multiple Medications Among Public Mental Health Service Users.Community mental health journal · 2020Article
- Antipsychotic Polypharmacy: A Dirty Little Secret or a Fashion?The international journal of neuropsychopharmacology · 2020Review
- The Prevalence and Factors Associated With Antipsychotic Polypharmacy in a Forensic Psychiatric Sample.Frontiers in psychiatry · 2020Article
- Article
- Social Determinants of Polypharmacy in First Generation Mexican Immigrants in the United States.International journal of travel medicine and global health · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of our study was to examine the prevalence of and factors associated with antipsychotic polypharmacy (APP) among patients with serious mental illness in the current South African health care context.
methodsWe collected data on patient, illness, and treatment characteristics of patients discharged on one or more antipsychotic agents from January to June 2014. We analyzed the associations of APP with demographic and clinical variables using hierarchical multivariable logistic regression, and examined prescription patterns.
resultsThe prevalence of APP in our study population of 577 patients was 28.4%. Demographic and clinical characteristics significantly associated with APP included age > 29, male sex, diagnosis of schizophrenia, comorbid intellectual disability, comorbid substance use, greater number of hospital admissions, and high-dose prescribing. First-generation antipsychotics and long-acting injectable preparations were prominent in APP combinations. Co-prescription of anticholinergic agents and sodium valproate demonstrated a significant association with APP.
conclusionAPP appears common in our population, despite lack of evidence for the practice and possible risk of harm. Our findings suggest a complex interplay among patient, illness, and treatment factors relevant to APP in our setting that could be targeted for intervention.
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