ReviewBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2017
Salivary cortisol and α-amylase: subclinical indicators of stress as cardiometabolic risk.
Review in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05315648 (The Associations Between Perioperative Depression or Anxiety, Salivary Cortisol and α-amylase, and Administered Anesthesia Type in Knee Arthroscopy With Anterior Cruciate Ligament Reconstruction), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Associations Between Perioperative Depression or Anxiety, Salivary Cortisol and α-amylase, and Administered Anesthesia Type in Knee Arthroscopy With Anterior Cruciate Ligament Reconstruction (ACLR): Prospective, Randomized Trial
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- The Effect of Acute Hypohydration on Indicators of Glycemic Regulation, Appetite, Metabolism and Stress: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Effect of 1% HInternational dental journal · 2024Trial
- Low salivary pH reflects high dental anxiety: evidence from a preliminary cross-sectional study.Odontology · 2026Observational
- Measurement of Dermal Ammonia Emission Using a Passive Flux Sampler and Its Association with Autonomic Nervous System Activity in Medical Workers: A Preliminary Study.Sensors (Basel, Switzerland) · 2026Article
- Optimizing Pediatric Patient Comfort: A Study of Moisture Isolation Techniques During Dental Treatments.Children (Basel, Switzerland) · 2026Article
- Steroid-related mechanisms in ocular health and disease: therapeutic effects, adverse events, and stress-related modulators. A narrative literature overview.Frontiers in medicine · 2026Review
- Psychobiological reactivity to acute psychological stress as a predictor of cardiovascular disease and mortality: The Multi-Ethnic Study of Atherosclerosis.Psychoneuroendocrinology · 2026Observational
- Sex-Specific Patterns of Cortisol Fluctuation, Stress, and Academic Success in Quarantined Foreign Medical Students During the COVID-19 Lockdown.Life (Basel, Switzerland) · 2025Article
- Stress-reducing effect of laughter in live comedy performance from salivary α-amylase and salivary oxytocin.BMC research notes · 2025Article
- Linking Premenstrual Syndrome With Salivary Alpha-Amylase Levels and Stress Levels: A Cross-Sectional Study.Journal of family & reproductive health · 2025Article
- The burnout: a silent saboteur in in vitro fertilization laboratories.Journal of assisted reproduction and genetics · 2025Review
- A clinical and biochemical study to estimate the salivary alpha-amylase level in post-menopausal women with psychosomatic disorders.African health sciences · 2025Article
- Unlocking optimism in everyday life: a short-term study on the power of live comedy to reduce stress and anxiety in general public.Health psychology and behavioral medicine · 2025Article
- Associations Between Salivary Cortisol, DHEA-S, and Alpha-Amylase and Longitudinal Sleep Disruption in Shift-Working Healthcare Professionals: A Pilot Study.Nature and science of sleep · 2025Article
- IL-6, calcium, salivary amylase activity and cortisol as a salivary biomarker-combination associated with obesity: a pilot study.Frontiers in dental medicine · 2025Article
- Stress and sleep deprivation-related biomarkers in saliva in patients with retinitis pigmentosa.PloS one · 2024Observational
- Evaluation of Stress Response in Middle-Aged Male Diabetic Hypertensive Patients.The Journal of clinical endocrinology and metabolism · 2023Article
- Investigation of possible relationship between atopic dermatitis and salivary biomarkers, stress, and sleep disorders.World journal of clinical cases · 2023Review
- Salivary Biomarkers Analysis and Neurobehavioral Assessment in Nurses Working Rotation Shifts: A Pilot Study.International journal of environmental research and public health · 2023Article
- Changes in stress pathways as a possible mechanism of aerobic exercise training on brain health: a scoping review of existing studies.Frontiers in physiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, the potential for cardiovascular (CV) stress-induced risk is primarily based on the theoretical (obvious) side effects of stress on the CV system. Salivary cortisol and α-amylase, produced respectively by the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic-adrenomedullary (SAM) system during stress response, are still not included in the routine evaluation of CV risk and require additional and definitive validation. Therefore, this article overviews studies published between 2010 and 2015, in which salivary cortisol and α-amylase were measured as stress biomarkers to examine their associations with CV/CMR (cardiometabolic risk) clinical and subclinical indicators. A comprehensive search of PubMed, Web of Science and Scopus electronic databases was performed, and 54 key articles related to the use of salivary cortisol and α-amylase as subclinical indicators of stress and CV/CMR factors, including studies that emphasized methodological biases that could influence the accuracy of study outcomes, were ultimately identified. Overall, the biological impact of stress measured by salivary cortisol and α-amylase was associated with CV/CMR factors. Results supported the use of salivary cortisol and α-amylase as potential diagnostic tools for detecting stress-induced cardiac diseases and especially to describe the mechanisms by which stress potentially contributes to the pathogenesis and outcomes of CV diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.