ArticleMemorias do Instituto Oswaldo Cruz2017
Linalool, a Piper aduncum essential oil component, has selective activity against Trypanosoma cruzi trypomastigote forms at 4°C.
Article in Memorias do Instituto Oswaldo Cruz, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Comparative Profiling and In Silico Multitarget Analysis of Volatile Constituents fromPlants (Basel, Switzerland) · 2026Article
- Linalool as a potential agent against Toxoplasma gondii: an in vitro study.BMC research notes · 2025Article
- Non-human primates as indicators of Kinetoplastida diversity in an urban environment in Midwest Brazil.Frontiers in parasitology · 2025Article
- A Promising Amphotericin B Derivative Induces Morphological Alterations, Mitochondrial Damage, and Oxidative Stress In Vitro and Prevents Mice from Death Produced by a Virulent Strain ofMicroorganisms · 2024Article
- Chemistry and Bioactivity ofMolecules (Basel, Switzerland) · 2023Article
- In Vitro Activity of Essential Oils fromMetabolites · 2023Article
- Phenoplasticity of Essential Oils from Two Species ofPlants (Basel, Switzerland) · 2022Article
- Anti-trypanosomal screening of Salvadoran flora.Journal of natural medicines · 2022Article
- In Vitro Anti-Plants (Basel, Switzerland) · 2021Article
- In Vitro Phenotypic Activity and In Silico Analysis of Natural Products from Brazilian Biodiversity onMolecules (Basel, Switzerland) · 2021Article
- Synergistic effect and ultrastructural changes in Trypanosoma cruzi caused by isoobtusilactone A in short exposure of time.PloS one · 2021Article
- Piper aduncum essential oil: a promising insecticide, acaricide and antiparasitic. A review.Parasite (Paris, France) · 2021Review
- Article
- Review
- Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses.Oxidative medicine and cellular longevity · 2019Review
- Induction of programmed cell death in Trypanosoma cruzi by Lippia alba essential oils and their major and synergistic terpenes (citral, limonene and caryophyllene oxide).BMC complementary and alternative medicine · 2018Article
- Essential Oils from Neotropical Piper Species and Their Biological Activities.International journal of molecular sciences · 2017Review
- Essential Oil from Piper aduncum: Chemical Analysis, Antimicrobial Assessment, and Literature Review.Medicines (Basel, Switzerland) · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies showed that essential oils from different pepper species (Piper spp.) have promising leishmanicidal and trypanocidal activities.
objectivesIn search for natural compounds against Trypanosoma cruzi, different forms of the parasite were incubated for 24 h at 28ºC or 4ºC with Piper aduncum essential oil (PaEO) or its main constituents linalool and nerolidol.
methodsPaEO chemical composition was obtained by GC-MS. Drug activity assays were based on cell counting, MTT data or infection index values. The effect of PaEO on the T. cruzi cell cycle and mitochondrial membrane potential was evaluated by flow cytometry.
findingsPaEO was effective against cell-derived (IC50/24 h: 2.8 μg/mL) and metacyclic (IC50/24 h: 12.1 μg/mL) trypomastigotes, as well as intracellular amastigotes (IC50/24 h: 9 μg/mL). At 4ºC - the temperature of red blood cells (RBCs) storage in blood banks - cell-derived trypomastigotes were more sensitive to PaEO (IC50/24 h = 3.8 μg/mL) than to gentian violet (IC50/24 h = 24.7 mg/mL). Cytotoxicity assays using Vero cells (37ºC) and RBCs (4ºC) showed that PaEO has increased selectivity for cell-derived trypomastigotes. Flow cytometry analysis showed that PaEO does not affect the cell cycle of T. cruzi epimastigotes, but decreases their mitochondrial membrane potential. GC-MS data identified nerolidol and linalool as major components of PaEO, and linalool had trypanocidal effect (IC50/24 h: 306 ng/mL) at 4ºC. MAIN
conclusionThe trypanocidal effect of PaEO is likely due to the presence of linalool, which may represent an interesting candidate for use in the treatment of potentially contaminated RBCs bags at low temperature.
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