Evidence map›Paper›PMID 28176973›Full record

ArticleHeart Asia2017

Changes in ischaemic ECG abnormalities and subsequent risk of cardiovascular disease.

Takeshi Sawai, Hironori Imano, Isao Muraki, Mina Hayama-Terada, Yuji Shimizu, Renzhe Cui, Akihiko Kitamura, Masahiko Kiyama, Takeo Okada, Tetsuya Ohira and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart Asia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Takeshi SawaiPublic Health, Department of Social Medicine , Osaka University Graduate School of Medicine , Osaka , Japan.
Hironori ImanoPublic Health, Department of Social Medicine , Osaka University Graduate School of Medicine , Osaka , Japan.
Isao MurakiOsaka Center for Cancer and Cardiovascular Disease Prevention , Osaka , Japan.
Mina Hayama-TeradaOsaka Center for Cancer and Cardiovascular Disease Prevention , Osaka , Japan.
Yuji ShimizuOsaka Center for Cancer and Cardiovascular Disease Prevention , Osaka , Japan.
Renzhe CuiPublic Health, Department of Social Medicine , Osaka University Graduate School of Medicine , Osaka , Japan.
Akihiko KitamuraPublic Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan; Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Masahiko KiyamaOsaka Center for Cancer and Cardiovascular Disease Prevention , Osaka , Japan.
Takeo OkadaOsaka Center for Cancer and Cardiovascular Disease Prevention , Osaka , Japan.
Tetsuya OhiraDepartment of Epidemiology , Fukushima Medical University School of Medicine , Fukushima , Japan.
Kazumasa YamagishiDepartment of Public Health Medicine, Faculty of Medicine , University of Tsukuba , Ibaraki , Japan.
Mitsumasa UmesawaDepartment of Public Health, Dokkyo Medical University School of Medicine , Tochigi , Japan.
Tomoko SankaiDepartment of Community Health, Faculty of Medicine , University of Tsukuba , Ibaraki , Japan.
Hiroyasu IsoPublic Health, Department of Social Medicine , Osaka University Graduate School of Medicine , Osaka , Japan.
Osaka Medical Center for Cancer and Cardiovascular Diseases · JPOsaka University · JPUniversity of Tsukuba · JPDokkyo Medical University · JPFukushima Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe prognostic importance of changes in ischaemic ECG abnormalities over time (especially ST-T abnormalities) among Asians has not been fully investigated. We examined the associations between changes in ischaemic abnormalities upon serial ECG (improvement, persistence, deterioration) and cardiovascular disease (CVD) risk.

methodsA prospective study cohort was conducted with 9374 men and women aged 40-69 years in four communities. Participants had multiple ECGs at study entry and during the next 10 years, and were followed up for a median period of 23.0 years. Total CVD (stroke and coronary heart disease) was ascertained under systematic surveillance. ECG abnormalities were defined by the Minnesota Code, ST depression (Code4), abnormal T wave (Code5) and categorised into nine groups (no-no, no-minor, no-major, minor-no, minor-minor, minor-major, major-no, major-minor, major-major) by comparison with the point of entrance and maximum change.

resultsWe documented 1196 CVD events. Compared with no-no abnormality, no-minor, minor-major and major-major in Code4, HRs (95% CI) adjusted for cardiovascular risk factors were 1.19 (1.00-1.42), 1.57 (1.15-2.12) and 1.87 (1.42-2.47). Similar results were observed in Code5.

conclusionsChanges in ischaemic ECG abnormalities from none to minor, and minor to major, as well as persistent major abnormalities, were associated with an increased risk of CVD.

Identifiers

PMID28176973
PMCPMC5278342
OpenAlexW2582282492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.