ReviewClinical and experimental gastroenterology2017
Autoimmune hepatitis: current challenges and future prospects.
Review in Clinical and experimental gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Diverse Subsets of γδT Cells and Their Specific Functions Across Liver Diseases.International journal of molecular sciences · 2025Review
- Elucidating the role of autoreactive T cells and B cells in autoimmune hepatitis.The Journal of clinical investigation · 2025Article
- Overlap syndromes in autoimmune liver disease: a review.Translational gastroenterology and hepatology · 2025Review
- Long-Term Prednisone Use Increases Hepatocellular Carcinoma Risk in Autoimmune Hepatitis Cirrhosis: A Retrospective Cohort Study.Gastro hep advances · 2025Article
- Drug-induced autoimmune-like hepatitis: A disproportionality analysis based on the FAERS database.PloS one · 2025Article
- Mesenchymal Stem Cell-Derived Exosomes: Emerging as a Promising Cell-Free Therapeutic Strategy for Autoimmune Hepatitis.Biomolecules · 2024Review
- Clinical Characteristics of Autoimmune Hepatitis in a Middle Eastern Population: A Tertiary Care Center Experience.Journal of clinical medicine · 2023Article
- Centrilobular zonal necrosis is a unique subtype of autoimmune hepatitis: A cohort study.Medicine · 2022Article
- Autoimmune Hepatitis Associated With Cryoglobulinemic Vasculitis.ACG case reports journal · 2022Article
- Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients.Journal of cancer research and clinical oncology · 2022Observational
- In the presence of autoantibodies and iron overload, do not judge a book by its cover: A case report.Hepatology forum · 2021Article
- Renaming NAFLD to MAFLD: Could the LDE System Assist in This Transition?Journal of clinical medicine · 2021Review
- DNA Microsystems for Biodiagnosis.Micromachines · 2020Review
- Autoimmune hepatitis in human immunodeficiency virus-infected patients: A case series and review of the literature.World journal of gastroenterology · 2019Review
- Enhanced Th17 Responses in Patients with Autoimmune Hepatitis.Middle East journal of digestive diseases · 2019Article
- Pediatric Fatty Liver and Obesity: Not Always Justa Matter of Non-Alcoholic Fatty Liver Disease.Children (Basel, Switzerland) · 2018Review
- Cytotoxic T lymphocyte antigen-4 gene polymorphisms and susceptibility to type 1 autoimmune hepatitis in the Tunisian population.Genes & diseases · 2018Article
- Acute-onset Autoimmune Hepatitis in a Young Woman with Type 1 Diabetes Mellitus.Internal medicine (Tokyo, Japan) · 2018Article
- γδ T cells in liver diseases.Frontiers of medicine · 2018Review
- Potential triggering factors of acute liver failure as a first manifestation of autoimmune hepatitis-a single center experience of 52 adult patients.World journal of gastroenterology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune hepatitis (AIH) is a chronic progressive liver disease characterized by high levels of aminotransferases and autoantibodies, hypergammaglobulinemia, and interface hepatitis. AIH affects all races and all ages worldwide, regardless of sex, although a preponderance of females is a constant finding. The etiology of AIH has not been completely elucidated, but immunogenetic background and environmental parameters may contribute to its development. The most important genetic factor is human leukocyte antigens (HLAs), especially HLA-DR, whereas the role of environmental factors is not completely understood. Immunologically, disruption of the immune tolerance to autologous liver antigens may be a trigger of AIH. The diagnosis of classical AIH is fairly easy, though not without pitfalls. In contrast, the diagnosis of atypical AIH poses great challenges. There is confusion as to the definition of the disease entity and its boundaries in the diagnosis of overlap syndrome, drug-induced autoimmune hepatitis, and AIH with concomitant nonalcoholic fatty liver disease (NAFLD) or chronic hepatitis C. Centrilobular zonal necrosis is now included in the histological spectrum of AIH. However, the definition and the significance of AIH presenting with centrilobular zonal necrosis have not been examined extensively. In ~20% of AIH patients who are treated for the first time with standard therapy, remission is not achieved. The development of more effective and better tolerated novel therapies is an urgent need. In this review, we discuss the current challenges and the future prospects in relation to the diagnosis and treatment of AIH, which have been attracting considerable recent attention.
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