ArticleScientific reports2017
A novel human artery model to assess the magnetic accumulation of SPIONs under flow conditions.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Effect of clinically relevant iron oxide nanoparticles on macrophage polarization, tumor growth and tumor microenvironment modulation.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- Generalized blood vessel models for magnetic nanoparticle-based oncology: geometric and microfluidic properties.Scientific reports · 2026Article
- Article
- Opportunities and Challenges of Switchable Materials for Pharmaceutical Use.Pharmaceutics · 2022Review
- Targeted thrombolysis by magnetoacoustic particles in photothrombotic stroke model.Biomaterials research · 2022Article
- Investigation of Wall Shear Stress in Cardiovascular Research and in Clinical Practice-From Bench to Bedside.International journal of molecular sciences · 2021Review
- Synthesis, Principles, and Properties of Magnetite Nanoparticles for In Vivo Imaging Applications-A Review.Pharmaceutics · 2019Review
- Magnetic Accumulation of SPIONs under Arterial Flow Conditions: Effect of Serum and Red Blood Cells.Molecules (Basel, Switzerland) · 2019Article
- Effects of PEGylation on capture of dextran-coated magnetic nanoparticles in microcirculation.International journal of nanomedicine · 2019Article
- From design to the clinic: practical guidelines for translating cardiovascular nanomedicine.Cardiovascular research · 2018Review
- Drug delivery to atherosclerotic plaques using superparamagnetic iron oxide nanoparticles.International journal of nanomedicine · 2018Article
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Authors and funding
9 authors.
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Abstract
Magnetic targeting utilises the properties of superparamagnetic iron oxide nanoparticles (SPIONs) to accumulate particles in specified vasculature regions under an external magnetic field. As the behaviour of circulating particles varies depending on nanoparticle characteristics, magnetic field strength and flow dynamics, we established an improved ex vivo model in order to estimate the magnetic capture of SPIONs in physiological-like settings. We describe here a new, easy to handle ex vivo model of human umbilical artery. Using this model, the magnetic targeting of different types of SPIONs under various external magnetic field gradients and flow conditions was investigated by atomic emission spectroscopy and histology. Among tested particles, SPION-1 with lauric acid shell had the largest capacity to accumulate at the specific artery segment. SPION-2 (lauric acid/albumin-coated) were also successfully targeted, although the observed peak in the iron content under the tip of the magnet was smaller than for SPION-1. In contrast, we did not achieve magnetic accumulation of dextran-coated SPION-3. Taken together, the umbilical artery model constitutes a time- and cost-efficient, 3R-compliant tool to assess magnetic targeting of SPIONs under flow. Our results further imply the possibility of an efficient in vivo targeting of certain types of SPIONs to superficial arteries.
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