Evidence map›Paper›PMID 28176805›Full record

ArticleScientific reports2017

Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt

Robert M Bragg, Sydney R Coffey, Rory M Weston, Seth A Ament, Jeffrey P Cantle, Shawn Minnig, Cory C Funk, Dominic D Shuttleworth, Emily L Woods, Bonnie R Sullivan and 10 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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  9. Early Downregulation of p75Molecular neurobiology · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Robert M BraggBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Sydney R CoffeyBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Rory M WestonBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Seth A AmentInstitute for Systems Biology, Seattle, WA, USA.
Jeffrey P CantleBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Shawn MinnigBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Cory C FunkInstitute for Systems Biology, Seattle, WA, USA.
Dominic D ShuttleworthBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Emily L WoodsBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Bonnie R SullivanBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Lindsey JonesBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Anne GlickenhausBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
John S AndersonBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Michael D AndersonBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Stephen B DunnettThe Brain Repair Group, Cardiff University School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, Wales CF10 3AX, United Kingdom.
Vanessa C WheelerCenter for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston 02114, MA, USA.
Marcy E MacDonaldCenter for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston 02114, MA, USA.
Simon P BrooksThe Brain Repair Group, Cardiff University School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, Wales CF10 3AX, United Kingdom.
Nathan D PriceInstitute for Systems Biology, Seattle, WA, USA.
Jeffrey B CarrollBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Western Washington University · USCardiff University · GBInstitute for Systems Biology · USMassachusetts General Hospital · USHarvard University · USUniversity of Maryland, Baltimore · US

Funding

Huntington's Disease Repeat Instability and PathogenesisR01NS049206 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VANESSA C WHEELER · 2005 to 2026
$10.0M
NINDS NIH HHS R01 NS049206
6 · The paper itself

Abstract

We investigated the appearance and progression of disease-relevant signs in the B6.Htt

Identifiers

PMID28176805
PMCPMC5296868
OpenAlexW2538549511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.