ArticleNature communications2017
Innovation and constraint leading to complex multicellularity in the Ascomycota.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Direct link between convergent evolution at sequence level and phenotypic level of septal pore cap in Agaricomycotina.G3 (Bethesda, Md.) · 2026Article
- A functional betalain-producing dioxygenase inIMA fungus · 2026Article
- A genomic perspective on fungal diversity and evolution.Nature reviews. Microbiology · 2025Review
- Phylogenomic signatures of repeat-induced point mutations across the fungal kingdom.PLoS biology · 2025Article
- Adaptive advantages of restorative RNA editing in fungi for resolving survival-reproduction trade-offs.Science advances · 2024Article
- Fungal taxonomy: A puzzle with many missing piecesBiomedica : revista del Instituto Nacional de Salud · 2023Article
- Lessons on fruiting body morphogenesis from genomes and transcriptomes ofStudies in mycology · 2023Article
- Woronin body hitchhiking on early endosomes is dispensable for septal localization inMolecular biology of the cell · 2023Article
- Large-scale identification of genes involved in septal pore plugging in multicellular fungi.Nature communications · 2023Article
- Local calcium signal transmission in mycelial network exhibits decentralized stress responses.PNAS nexus · 2023Article
- Woronin bodies move dynamically and bidirectionally by hitchhiking on early endosomes inbioRxiv : the preprint server for biology · 2023Article
- Evolution of fungal phenotypic disparity.Nature ecology & evolution · 2022Article
- Evolutionary Morphogenesis of Sexual Fruiting Bodies in Basidiomycota: Toward a New Evo-Devo Synthesis.Microbiology and molecular biology reviews : MMBR · 2022Review
- Article
- Genome Comparisons of the Fission Yeasts Reveal Ancient Collinear Loci Maintained by Natural Selection.Journal of fungi (Basel, Switzerland) · 2021Article
- Analysis of Fungal Genomes Reveals Commonalities of Intron Gain or Loss and Functions in Intron-Poor Species.Molecular biology and evolution · 2021Article
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- Improving Fungal Cultivability for Natural Products Discovery.Frontiers in microbiology · 2021Review
- Mosaic fungal individuals have the potential to evolve within a single generation.Scientific reports · 2020Article
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Abstract
The advent of complex multicellularity (CM) was a pivotal event in the evolution of animals, plants and fungi. In the fungal Ascomycota, CM is based on hyphal filaments and arose in the Pezizomycotina. The genus Neolecta defines an enigma: phylogenetically placed in a related group containing mostly yeasts, Neolecta nevertheless possesses Pezizomycotina-like CM. Here we sequence the Neolecta irregularis genome and identify CM-associated functions by searching for genes conserved in Neolecta and the Pezizomycotina, which are absent or divergent in budding or fission yeasts. This group of 1,050 genes is enriched for functions related to diverse endomembrane systems and their organization. Remarkably, most show evidence for divergence in both yeasts. Using functional genomics, we identify new genes involved in fungal complexification. Together, these data show that rudimentary multicellularity is deeply rooted in the Ascomycota. Extensive parallel gene divergence during simplification and constraint leading to CM suggest a deterministic process where shared modes of cellular organization select for similarly configured organelle- and transport-related machineries.
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