Evidence map›Paper›PMID 28176776›Full record

ArticleEuropean journal of clinical nutrition2017

Dietary intake of whole grains and plasma alkylresorcinol concentrations in relation to changes in anthropometry: the Danish diet, cancer and health cohort study.

C Kyrø, M Kristensen, M U Jakobsen, J Halkjær, R Landberg, Hb As Bueno-de-Mesquita, J Christensen, I Romieu, A Tjønneland, A Olsen

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

C KyrøUnit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
M KristensenDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
M U JakobsenDepartment of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
J HalkjærUnit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
R LandbergDepartment of Food Science, BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Hb As Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
J ChristensenUnit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
I RomieuNutrition and Metabolism Section, International Agency for Research on Cancer (WHO-IARC), Lyon, France.
A TjønnelandUnit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
A OlsenUnit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.

Funding

World Health Organization 001
6 · The paper itself

Abstract

BACKGROUND/

objectivesWhole grain intake has been associated with a small but significant lower body weight gain in observational studies, but there is limited knowledge about the associations with specific whole grain types. The objective was to investigate the association between whole grains, different sources of whole grains and biomarkers of whole grain intake (alkylresorcinols) in relation to subsequent changes in waist circumference (WC) and body weight. SUBJECTS/

methodsCohort study of 57 053 participants with baseline information on whole grain intake from questionnaires (FFQ) and biomarkers of whole grain rye and wheat intake, plasma alkylresorcinols, for a subset. WC and body weight were measured at baseline and again at follow-up. The associations were estimated using multiple linear regression analyses and logistic regression.

resultsFor women, overall whole grain intake was not related to changes in WC or body weight. For men, total whole grain intake was associated with gains in WC (ΔWC per 25 g increment: 0.44 cm, 95% CI: 0.34 cm; 0.54 cm) and body weight (Δweight per 25 g increment: 150 g, 95% CI: 78 g; 222 g), but the results changed to null or changed direction when adjusting for baseline anthropometry. For the different sources of whole grains, rye (women) and crispbread was significantly associated with gains in WC and body weight. Plasma alkylresorcinol concentration was associated with reduced WC, but not body weight, for women (ΔWC per 50 nmol/l increment: -0.69 cm, 95% CI:-1.26 cm;-0.13 cm), but no association was found for men.

conclusionsOverall, no strong relationship between whole grain intake, measured from questionnaires or using biomarkers was found in relation to changes in body weight and WC.

Indexed as

Diet, HealthyPatient ComplianceSecaleTriticumWhole GrainsAlkylationBiomarkersCohort StudiesCross-Sectional StudiesDenmarkFemaleFollow-Up StudiesHumansMaleMiddle AgedOverweightBiomarkersResorcinols

Identifiers

PMID28176776

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.