Evidence map›Paper›PMID 28176763›Full record

ArticleNature communications2017

p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.

Ashwini Hinge, Juying Xu, Jose Javier, Eucabeth Mose, Sachin Kumar, Reuben Kapur, Edward F Srour, Punam Malik, Bruce J Aronow, Marie-Dominique Filippi

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  4. Linking cell cycle to hematopoietic stem cell fate decisions.Frontiers in cell and developmental biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ashwini HingeDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
Juying XuDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
Jose JavierDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
Eucabeth MoseDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
Sachin KumarDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
Reuben KapurDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Edward F SrourDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Punam MalikDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
Bruce J AronowDivision of Biomedical Informatics, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
Marie-Dominique FilippiDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati Medical Center · USIndiana University – Purdue University Indianapolis · US

Funding

Progenitor Cell Biology Consortium Administrative Coordinating CenterU01HL099997 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L · 2009 to 2015
$29.9M
Role of p21 activated kinase in LeukemogenesisR01CA173852 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI KAPUR, REUBEN · 2014 to 2025
$3.4M
Regulation of hematopoietic stem cell self-renewal by GTPase activating protein signalingR01DK102890 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI FILIPPI, MARIE-DOMINIQUE, MALIK, PUNAM · 2015 to 2018
$1.7M
Regulation of Hematopoietic Stem Cell Self RenewalR21HL104458 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI FILIPPI, MARIE-DOMINIQUE · 2010 to 2011
$420k
NCI NIH HHS R01 CA173852NHLBI NIH HHS R21 HL104458NHLBI NIH HHS U01 HL099997NIDDK NIH HHS R01 DK102890
6 · The paper itself

Abstract

The mechanisms regulating hematopoietic stem and progenitor cell (HSPC) fate choices remain ill-defined. Here, we show that a signalling network of p190-B RhoGAP-ROS-TGF-β-p38

Indexed as

AnimalsCell DifferentiationCells, CulturedCell Self RenewalCytokinesGTPase-Activating ProteinsHematopoietic Stem CellsHematopoietic Stem Cell TransplantationMiceMice, Inbred C57BLMice, Transgenicp38 Mitogen-Activated Protein KinasesPrimary Cell CultureReactive Oxygen SpeciesSignal TransductionSingle-Cell AnalysisArhgap5 protein, mouseCytokinesGTPase-Activating Proteinsp38 Mitogen-Activated Protein KinasesReactive Oxygen SpeciesTransforming Growth Factor beta

Identifiers

PMID28176763
PMCPMC5309857
OpenAlexW2586370935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.