ArticleJournal of exposure science & environmental epidemiology2018
Systemic serum amyloid A as a biomarker for exposure to zinc and/or copper-containing metal fumes.
Article in Journal of exposure science & environmental epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Welding fume exposure and respiratory innate immune activation: metal-rich particles, inflammatory biomarkers, and immune-informed occupational prevention.Frontiers in immunology · 2026Review
- Type 2 diabetes mellitus and zinc dysregulation: From basic and epidemiological evidence to interventions.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025Review
- Occupationally Relevant Zinc- and Copper-Containing Metal Fumes Inhibit Human THP-1 Macrophage TNF and IL-6 Responses to Bacterial Stimuli.Global challenges (Hoboken, NJ) · 2025Article
- Inflammatory Responses to Zn/Cu-Containing Welding Fume in Human Alveolar Epithelial and Macrophage Cell Lines, with MIP-1β/CCL4 as a Much More Sensitive Macrophage Activation Marker than IL-8 and TNF-α.International journal of molecular sciences · 2025Article
- Acute phase response following pulmonary exposure to soluble and insoluble metal oxide nanomaterials in mice.Particle and fibre toxicology · 2023Article
- The human long noncoding RNAs CoroMarker, MALAT1, CDR1as, and LINC00460 in whole blood of individuals after controlled short-term exposure with ultrafine metal fume particles at workplace conditions, and in human macrophages in vitro.Journal of occupational medicine and toxicology (London, England) · 2022Article
- Latent Toxoplasma gondii infections are associated with elevated biomarkers of inflammation and vascular injury.BMC infectious diseases · 2021Article
- Effects of mild steel welding fume particles on pulmonary epithelial inflammation and endothelial activation.Toxicology and industrial health · 2020Article
- Human Cytomegalovirus Infections Are Associated With Elevated Biomarkers of Vascular Injury.Frontiers in cellular and infection microbiology · 2020Article
- Article
- Association between a urinary biomarker for exposure to PAH and blood level of the acute phase protein serum amyloid A in coke oven workers.Environmental health : a global access science source · 2019Article
- Editorial: dose-dependent ZnO particle-induced acute phase response in humans warrants re-evaluation of occupational exposure limits for metal oxides.Particle and fibre toxicology · 2018Article
- Concentration-dependent systemic response after inhalation of nano-sized zinc oxide particles in human volunteers.Particle and fibre toxicology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc- and copper-containing welding fumes increase systemic C-reactive protein (CRP). The aim of this study was to investigate the performance of the biomarkers serum amyloid A (SAA) and soluble vascular cell adhesion molecule-1 (VCAM-1) in this regard. Fifteen male subjects were exposed under controlled conditions to welding fumes containing either zinc, or copper, or copper and zinc for 6 h. Plasma samples were collected before, 6 and 24 h after start of exposure and biomarkers therein were measured by electrochemiluminescent assay. For each exposure, systemic concentrations of systemic SAA, but not VCAM-1, increased significantly at 24 h after exposure start compared with baseline ("copper only": P=0.0005, "zinc only": P=0.027, "copper and zinc": P=0.001). SAA showed a wider range of concentrations than did CRP and its levels increased up to 19-fold after welding fume exposure. The recognition of copper as a potential harmful component in welding fumes, also independent from zinc, deserves further consideration. SAA might represent a new sensitive biomarker for potential subclinical sterile inflammation after inhalation of copper- and/or zinc-containing welding fumes. As elevations of CRP and SAA protein have both been linked to a higher risk for cardiovascular disease, these findings might particularly be important for long-term welders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.