ArticlePharmaceutical biology2017
Inhibition of key enzymes linked to type 2 diabetes by compounds isolated from Aframomum melegueta fruit.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 51 citations in OpenAlex.
- Insights into biological activities profile of gingerols and shogaols for potential pharmacological applications.Archives of pharmacal research · 2025Review
- Phytochemical analysis, antioxidant, anti-inflammatory and enzyme inhibitory activities of bean pear (Frontiers in plant science · 2025Article
- Phytochemical analysis and immunomodulatory activities in vitro and in vivo of Aframomum melegueta K Schum seed extracts.Inflammopharmacology · 2024Article
- Article
- Investigation of the antimicrobial, antioxidant, hemolytic, and thrombolytic activities ofFood science & nutrition · 2023Article
- A study on the effect of natural products against the transmission of B.1.1.529 Omicron.Virology journal · 2023Review
- Pharmacologically Active Phytomolecules Isolated from Traditional Antidiabetic Plants and Their Therapeutic Role for the Management of Diabetes Mellitus.Molecules (Basel, Switzerland) · 2022Review
- Bioreactor-grown exo- and endo-β-glucan from MalaysianFrontiers in bioengineering and biotechnology · 2022Article
- Protective effect of 6-paradol in acetic acid-induced ulcerative colitis in rats.BMC complementary medicine and therapies · 2021Article
- Antidiabetic Medicinal Plants Used in Democratic Republic of Congo: A Critical Review of Ethnopharmacology and Bioactivity Data.Frontiers in pharmacology · 2021Review
- Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources.Frontiers in pharmacology · 2021Review
- Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants.Plant methods · 2019Review
- Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus.Frontiers in pharmacology · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe use of Aframomum melegueta K. Schum. (Zingiberaceae) fruit for treatment of diabetes has recently been established in Nigeria. However, compounds responsible for the antidiabetic action have not been identified.
objectiveThe present study carried out the bioassay-guided isolation of possible bioactive compounds responsible for the antidiabetic action of A. melegueta fruit. MATERIALS AND
methodsThe A. melegueta fruit was sequentially extracted using ethyl acetate (EtOAc), ethanol and water, and the most active extract (EtOAc) was subjected to column chromatography on a silica gel column using solvent gradient systems of hexane (HEX):EtOAc and EtOAc:MeOH and the isolation of compounds was guided by α-glycosidase and α-amylase inhibitory activities at various concentrations (30-240 μg/mL).
resultsAccording to the results, 3 arylalkanes, 6-paradol (1), 6-shogaol (2) and 6-gingerol (3) and a pentacyclic triterpene, oleanolic acid (4) were isolated from A. melegueta fruit. All the compounds exhibited inhibitory effects against α-amylase and α-glucosidase. 6-Gingerol (3) and oleanolic acid (4) showed higher inhibitory activity against α-amylase (IC
conclusionThe data of this study suggest that the 6-gingerol (3) and oleanolic acid (4) showed higher α-amylase and α-glucosidase inhibitory action and therefore could be responsible for the antidiabetic activity of A. melegueta fruit.
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