ArticleAlimentary pharmacology & therapeutics2017
Inflammatory bowel diseases in Faroese-born Danish residents and their offspring: further evidence of the dominant role of environmental factors in IBD development.
Article in Alimentary pharmacology & therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Changing epidemiology of immune-mediated inflammatory diseases in immigrants: A systematic review of population-based studies.Journal of autoimmunity · 2019Pooled it
- Compounding Prevalence of Inflammatory Bowel Disease in a 2024 Population-Based Study From Canterbury, New Zealand.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Sex-specific and socioeconomic disparities in the global burden of inflammatory bowel disease in 204 countries, 1990-2021: projections to 2050.Frontiers in immunology · 2025Article
- Health effects associated with measured contaminants in the Arctic: short communication.International journal of circumpolar health · 2024Article
- Comparing Environmental Risk Factors at Diagnosis in Faroese and Danish Patients with Inflammatory Bowel Disease.Digestive diseases and sciences · 2024Article
- Inflammatory bowel disease among first generation immigrants in Israel: A nationwide epi-Israeli Inflammatory Bowel Disease Research Nucleus study.World journal of methodology · 2023Article
- A nationwide study of autoimmune liver diseases in the Faroe Islands: Incidence, prevalence, and causes of death 2004 - 2021.International journal of circumpolar health · 2023Article
- Similar Gut Bacterial Composition Between Patients With Ulcerative Colitis and Healthy Controls in a High Incidence Population: A Cross-sectional Study of the Faroe Islands IBD Cohort.Inflammatory bowel diseases · 2022Article
- Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients.Frontiers in medicine · 2022Article
- Mechanism underlying the significant role of the miR-4262/SIRT1 axis in children with inflammatory bowel disease.Experimental and therapeutic medicine · 2020Article
- High incidence of dementia in Faroese-born female residents in Denmark.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Dietary risk factors for inflammatory bowel diseases in a high-risk population: Results from the Faroese IBD study.United European gastroenterology journal · 2019Article
- Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science.Cells · 2019Review
- The Natural History of IBD: Lessons Learned.Current treatment options in gastroenterology · 2018Review
- Epidemiology of inflammatory bowel disease in racial and ethnic migrant groups.World journal of gastroenterology · 2018Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of inflammatory bowel disease (IBD) is record high in the Faroe Islands, and many Faroese emigrate to Denmark, where the IBD incidence is considerably lower.
aimTo study the IBD incidence in first-, second- and third-generation immigrants from the Faroe Islands to Denmark to assess the extent to which the immigrants adopt the lower IBD incidence of their new home country.
methodsData on Faroese-born Danish residents and their children were retrieved from the Danish Central Population Register for 1980-2014. Incident IBD cases were identified from the Danish National Patient Register. Standardised Incidence Ratios (SIRs) were used to compare the IBD risk in immigrants with that of Danes. 95% confidence intervals (CI) were calculated using the square-root transform.
resultsFirst-generation Faroese immigrants had a higher IBD incidence than Danes, SIR 1.25 (95% CI, 0.97-1.59) for men and 1.28 (95% CI, 1.05-1.53) for women. This excess risk derived from ulcerative colitis (UC), SIR 1.44 (95% CI, 1.10-1.87) for men and 1.36 (95% CI, 1.09-1.68) for women. No excess risk was found for Crohn's disease (CD). The UC risk was nearly doubled during the immigrants' first 10 years in Denmark; SIR 2.13 (95% CI, 1.52-2.92) for men and 1.63 (95% CI, 1.19-2.18) for women.
conclusionsAlthough some impact of genetic dilution cannot be excluded, our findings indicate importance of gene-environment interplay in UC, as the excess UC risk in Faroese immigrants to Denmark disappeared over time and over one generation in men and over two generations in women.
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