Evidence map›Paper›PMID 28176238›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2017

Vitamin D status in patients with cirrhosis of the liver and their relatives-A case control study from North India.

Ravikant Kumar, Pavan Kumar, Kandarp Nath Saxena, Manjul Mishra, Vivek Kumar Mishra, Anju Kumari, Manisha Dwivedi, Sri Prakash Misra

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Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Vitamin D status & bone health in patients with liver cirrhosis.The Indian journal of medical research · 2023
    Article
  5. Short-term mortality in patients with cirrhosis of the liver and acute kidney injury: A prospective observational study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020
    Observational
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ravikant KumarDepartment of Gastroenterology and Hepatology, M L N Medical College, Allahabad, 211 001, India. drravi0609@gmail.com.
Pavan KumarDepartment of Gastroenterology and Hepatology, M L N Medical College, Allahabad, 211 001, India.
Kandarp Nath SaxenaDepartment of Gastroenterology and Hepatology, M L N Medical College, Allahabad, 211 001, India.
Manjul MishraDepartment of Gastroenterology and Hepatology, M L N Medical College, Allahabad, 211 001, India.
Vivek Kumar MishraDepartment of Gastroenterology and Hepatology, M L N Medical College, Allahabad, 211 001, India.
Anju KumariDepartment of Physiology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, 800 014, India.
Manisha DwivediDepartment of Gastroenterology and Hepatology, M L N Medical College, Allahabad, 211 001, India.
Sri Prakash MisraDepartment of Gastroenterology and Hepatology, M L N Medical College, Allahabad, 211 001, India.
Motilal Nehru Medical College · INIndira Gandhi Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimLiver diseases interfere with the production of the metabolites of vitamin D required for activation, thus resulting in abnormal calcium and bone metabolism. Previous studies show inconsistent results of vitamin D level in non-cholestatic liver diseases. Our aim was to determine the prevalence of vitamin D insufficiency in cirrhosis as compared to apparently normal relatives and its relationship with etiology and severity.

methodsOne hundred and sixty cirrhotic patients attending the Department of Gastroenterology and Hepatology, M L N Medical College, Allahabad, were enrolled, and 25-hydroxy vitamin D [25(OH)D] and calcium levels assessed. Vitamin D status was graded as insufficiency (20-30 ng/mL), deficiency (<20 ng/mL), and severe deficiency (<7 ng/mL). 25(OH)D levels of patients were compared with those of their healthy family members.

resultsForty-six percent of the normal population had 25(OH)D inadequacy, whereas 51.85% of patients with cirrhosis had 25(OH)D deficiency, and 28.12% had insufficiency. Thus, 80% of patients with cirrhosis of the liver had some form of vitamin D inadequacy. 12.5% of cirrhotics had severe vitamin D deficiency. Serum calcium (Ca

conclusionVitamin D insufficiency is highly prevalent in patients with cirrhosis irrespective of etiology and significantly more common than their healthy relatives. Measurement of 25(OH) vitamin D and replacement may be considered as part of the overall management of patients with cirrhosis of the liver as well as apparently healthy individuals.

Indexed as

AdultCase-Control StudiesFemaleHumansIndiaLiver CirrhosisMaleMiddle AgedPrevalenceVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin DChild-Turcotte-Pugh scoreCirrhosisModel for end-stage liver disease scoreVitamin D

Identifiers

PMID28176238
OpenAlexW2587551428

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.