ArticleClinical rheumatology2017
Association of serum uric acid and risk of hypertension in adults: a prospective study of Kailuan Corporation cohort.
Article in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Threshold effect of the METS-VF index on hyperuricemia in adults with hypertension: a cross-sectional study.BMC endocrine disorders · 2026Article
- Association between uric acid to albumin ratio and all-cause mortality among United States adults: An observational study.Medicine · 2025Observational
- Article
- Uric acid level in climacteric women and its association with clinical and metabolic parameters.Scientific reports · 2023Article
- Association between hyperuricemia and hypertension and the mediatory role of obesity: a large cohort study in China.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Validation of age- and sex-dependent association of uric acid and incident hypertension in rural areas.Clinical hypertension · 2022Article
- Association of self-reported snoring and hyperuricaemia: a large cross-sectional study in Chongqing, China.BMJ open · 2022Article
- Prevalence of Hyperuricemia and the Relationship Between Serum Uric Acid and Hypertension in New Onset Diabetic Patients: A Cross-Sectional Indian Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Individual and combined association analysis of famine exposure and serum uric acid with hypertension in the mid-aged and older adult: a population-based cross-sectional study.BMC cardiovascular disorders · 2021Article
- Epidemiologic Profile of Hypertension in Northern Iranian Population: The PERSIAN Guilan Cohort Study (PGCS).Annals of global health · 2021Article
- The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults.Cardiovascular therapeutics · 2021Article
- Urine Uric Acid Excretion Levels are Positively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Patients without Chronic Kidney Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- The interaction between serum uric acid and triglycerides level on blood pressure in middle-aged and elderly individuals in China: result from a large national cohort study.BMC cardiovascular disorders · 2020Article
- Article
- Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study.Frontiers in medicine · 2020Article
- Clinical characteristics of patients under 40 years old with early-onset hyperuricaemia: a retrospective monocentric study in China.BMJ open · 2019Article
- Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults.Scientific reports · 2019Article
- A Comparison on Prevalence of Hypertension and Related Risk Factors between Island and Rural Residents of Dalian City, China.International journal of hypertension · 2019Article
- Asymptomatic hyperuricemia: is it time to intervene?Clinical rheumatology · 2017Review
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15 authors.
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Abstract
Whether hyperuricemia is an independent risk factor for hypertension in adults is still under debate. To determine the association between serum uric acid and risk of hypertension in the Chinese population, we conducted a prospective study using the "Kailuan Corporation cohort." A total of 39,233 adult subjects with available data on serum uric acid were enrolled from 2006 to 2007. Subjects with established hypertension were excluded and were then grouped based on the gender and baseline quartile serum uric acid into F1-4 for women and M1-4 for men with F1 and M1 being the lowest quartiles. Incidence of newly described primary hypertension was reevaluated in 2010-2011. The median (interquantile range) baseline uric acid (UA) was 290 (243-344) μmol/L in men and 230 (194-274) μmol/L in women. During a 4-year follow-up period, 12,844 subjects (31.31 %) were newly diagnosed with hypertension. The incidence of hypertension was 14.36, 16.57, 19.06, and 22.35 % in F1 to F4 and 33.64, 33.97, 36.54, and 40.74 % in M1 to M4, respectively. Multiple logistic regression analysis showed that the odds ratios (ORs) of incident hypertension were 1.17 [95 % confidence interval (CI) 1.00-1.37, P = 0.055], 1.24 (95 % CI 1.06-1.45, P = 0.009), and 1.20 (95 % CI 1.02-1.41, P = 0.027) in F2 to F4 compared to the F1 and 0.98 (95 % CI 0.91-1.05, P = 0.534), 1.05 (95 % CI 0.98-1.13, P = 0.190), and 1.13 (95 % CI 1.05-1.22, P = 0.002) in M2 to M4 compared to the M1. Elevated level of serum uric acid is associated with an increased risk of hypertension in adults.
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