Evidence map›Paper›PMID 28175980›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

Spine fracture prevalence in a nationally representative sample of US women and men aged ≥40 years: results from the National Health and Nutrition Examination Survey (NHANES) 2013-2014.

F Cosman, J H Krege, A C Looker, J T Schousboe, B Fan, N Sarafrazi Isfahani, J A Shepherd, K D Krohn, P Steiger, K E Wilson and 1 more

Open access · greenAbstract read
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.

  1. Updated practice guideline for dual-energy X-ray absorptiometry (DXA).European journal of nuclear medicine and molecular imaging · 2025
    Guideline
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  11. Conventional chest computed tomography-based radiomics for predicting the risk of thoracolumbar osteoporotic vertebral fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  12. Article
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  14. Real-world rates and risk factors for subsequent treatment with vertebroplasty or balloon kyphoplasty after initial vertebral augmentation: a retrospective cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  15. Article
  16. Fractures of the thoracolumbar spine in osteoporosis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. ESTES recommendation on thoracolumbar spine fractures : January 2023.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

F CosmanRegional Bone Center, Helen Hayes Hospital, Route 9W, West Haverstraw, NY, 10993, USA. felcosman@gmail.com.
J H KregeEli Lilly and Company, Indianapolis, IN, USA.
A C LookerNational Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD, USA.
J T SchousboeHealthPartners Institute and Park Nicollet Clinic, HealthPartners, Minneapolis, MN, USA.
B FanDepartment of Radiology, University of California, San Francisco, CA, USA.
N Sarafrazi IsfahaniNational Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD, USA.
J A ShepherdDepartment of Radiology, University of California, San Francisco, CA, USA.
K D KrohnEli Lilly and Company, Indianapolis, IN, USA.
P SteigerParexel International, Waltham, MA, USA.
K E WilsonHologic, Inc., Marlborough, MA, USA.
H K GenantDepartment of Radiology, University of California, San Francisco, CA, USA.
University of California, San Francisco · USCenters for Disease Control and Prevention · USEli Lilly (United States) · USHelen Hayes Hospital · USHologic (United States) · USPAREXEL International (United States) · USPark Nicollet Clinic · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Spine fracture prevalence is similar in men and women, increasing from <5 % in those <60 to 11 % in those 70-79 and 18 % in those ≥80 years. Prevalence was higher with age, lower bone mineral density (BMD), and in those meeting criteria for spine imaging. Most subjects with spine fractures were unaware of them.

introductionSpine fractures have substantial medical significance but are seldom recognized. This study collected contemporary nationally representative spine fracture prevalence data.

methodsCross-sectional analysis of 3330 US adults aged ≥40 years participating in NHANES 2013-2014 with evaluable Vertebral Fracture Assessment (VFA). VFA was graded by semiquantitative measurement. BMD and an osteoporosis questionnaire were collected.

resultsOverall spine fracture prevalence was 5.4 % and similar in men and women. Prevalence increased with age from <5 % in those <60 to 11 % in those 70-79 and 18 % in those ≥80 years. Fractures were more common in non-Hispanic whites and in people with lower body mass index and BMD. Among subjects with spine fracture, 26 % met BMD criteria for osteoporosis. Prevalence was higher in subjects who met National Osteoporosis Foundation (NOF) criteria for spine imaging (14 vs 4.7 %, P < 0.001). Only 8 % of people with a spine fracture diagnosed by VFA had a self-reported fracture, and among those who self-reported a spine fracture, only 21 % were diagnosed with fracture by VFA.

conclusionSpine fracture prevalence is similar in women and men and increases with age and lower BMD, although most subjects with spine fracture do not meet BMD criteria for osteoporosis. Since most (>90 %) individuals were unaware of their spine fractures, lateral spine imaging is needed to identify these women and men. Spine fracture prevalence was threefold higher in individuals meeting NOF criteria for spine imaging (∼1 in 7 undergoing VFA). Identifying spine fractures as part of comprehensive risk assessment may improve clinical decision making.

Indexed as

AdultAgedAged, 80 and overAge DistributionBone DensityCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysOsteoporotic FracturesPrevalenceSex DistributionSpinal FracturesUnited StatesOsteoporosisPrevalenceScreeningSpine fractureVertebral Fracture Assessment (VFA)

Identifiers

PMID28175980
PMCPMC7422504
OpenAlexW2586579048

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.