ArticleNucleic acids research2017
Natural antisense transcripts are significantly involved in regulation of drought stress in maize.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Antisense Transcription in Plants: A Systematic Review and an Update on cis-NATs of Sugarcane.International journal of molecular sciences · 2022Pooled it
- H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants.Nature communications · 2026Article
- Epigenetic modifications in plant abiotic stress adaptation: towards climate-resilient and sustainable crop improvement.Frontiers in plant science · 2026Review
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Drought stress memory in maize: understanding and harnessing the past for future resilience.Plant cell reports · 2025Review
- Genome-wide view and characterization of natural antisense transcripts in Cannabis Sativa L.Plant molecular biology · 2024Article
- Identification and Functional Analysis of Drought-Responsive Long Noncoding RNAs in Maize Roots.International journal of molecular sciences · 2023Article
- Global identification of natural antisense transcripts iniScience · 2023Article
- Epigenomics in stress tolerance of plants under the climate change.Molecular biology reports · 2023Review
- Developing drought-smart, ready-to-grow future crops.The plant genome · 2023Review
- CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles.Scientific reports · 2022Article
- Broad-spectrum fungal resistance in sorghum is conferred through the complex regulation of an immune receptor gene embedded in a natural antisense transcript.The Plant cell · 2022Article
- Tissue-specific transcriptomic analysis uncovers potential roles of natural antisense transcripts inFrontiers in plant science · 2022Article
- Moving Beyond DNA Sequence to Improve Plant Stress Responses.Frontiers in genetics · 2022Review
- Methylation hallmarks on the histone tail as a linker of osmotic stress and gene transcription.Frontiers in plant science · 2022Review
- Non-Coding RNAs in Response to Drought Stress.International journal of molecular sciences · 2021Review
- Exploitation of Drought Tolerance-Related Genes for Crop Improvement.International journal of molecular sciences · 2021Review
- Maize DNA Methylation in Response to Drought Stress Is Involved in Target Gene Expression and Alternative Splicing.International journal of molecular sciences · 2021Article
- Identification of long noncoding natural antisense transcripts (lncNATs) correlated with drought stress response in wild rice (Oryza nivara).BMC genomics · 2021Article
- Genome-wide identification and functional characterization of natural antisense transcripts in Salvia miltiorrhiza.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural antisense transcripts (NATs) are a prominent and complex class of regulatory RNAs. Using strand-specific RNA sequencing, we identified 1769 sense and antisense transcript pairs (NAT pairs) in two maize inbreds with different sensitivity to drought, as well as in two derivative recombination inbred lines (RILs). A significantly higher proportion of NATs relative to non-NATs are specifically expressed under water stress (WS). Surprisingly, expression of sense and antisense transcripts produced by NAT pairs is significantly correlated, particularly under WS. We found an unexpected large proportion of NATs with protein coding potential, as estimated by ribosome release scores. Small RNAs significantly accumulate within NAT pairs, with 21 nt smRNA particularly enriched in overlapping regions of these pairs of genes. The abundance of these smRNAs is significantly altered in the leafbladeless1 mutant, suggesting that these genes may be regulated by the tasiRNA pathway. Further, NATs are significantly hypomethylated and include fewer transposable element sequences relative to non-NAT genes. NAT gene regions also exhibit higher levels of H3K36me3, H3K9ac, and H3K4me3, but lower levels of H3K27me3, indicating that NAT gene pairs generally exhibit an open chromatin configuration. Finally, NAT pairs in 368 diverse maize inbreds and 19 segregating populations were specifically enriched for polymorphisms associated with drought tolerance. Taken together, the data highlight the potential impact of that small RNAs and histone modifications have in regulation of NAT expression, and the significance of NATs in response to WS.
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