ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Association of Diabetes and Insulin Therapy With Risk of Hospitalization for Infection and 28-Day Mortality Risk.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Comparative analysis of serious adverse effects of antidiabetic drugs and complications associated with type II diabetes mellitus.BMC pharmacology & toxicology · 2026Observational
- Glycemic control and blood product quality of Canadian blood donors with diabetes.Transfusion · 2026Article
- National trends and comparative outcomes of insulin versus non-insulin therapy in acute ischemic stroke patients treated with mechanical thrombectomy: a retrospective cohort study using the national inpatient sample.Neurosurgical review · 2026Article
- Cumulative Vulnerability in Cardiac Critical Care: A Framework for Understanding Healthcare-Associated Infections and Their Progression to Severe Infection and Sepsis.Medicina (Kaunas, Lithuania) · 2026Article
- Development and validation of a nomogram model for predicting unplanned readmission in patients with acute pancreatitis.Frontiers in endocrinology · 2026Article
- Stroke in Ghana: A Situational Analysis.Stroke research and treatment · 2025Review
- Association of ambient air pollution with hemoglobin levels and anemia in the general population of Korean adults.BMC public health · 2024Article
- Article
- Giant cell arteritis treatment patterns and rates of serious infections.Clinical and experimental rheumatology · 2022Article
- A Case of Fungemia Caused by Postoperative Chronic Lumbar Intervertebral Disc Infection.Case reports in surgery · 2022Article
- Risk Estimation for Infection in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention: Development and Validation of a Predictive Score.Frontiers in cardiovascular medicine · 2022Article
- Stroke-associated infection in patients with co-morbid diabetes mellitus is associated with in-hospital mortality.Frontiers in aging neuroscience · 2022Article
- Multidrug-ResistantThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Article
- Application of Peak Glucose Range and Diabetes Status in Mortality Risk Stratification in Critically Ill Patients with Sepsis.Diagnostics (Basel, Switzerland) · 2021Article
- The occurrence of urinary tract infection and determinant factors among diabetic patients at Dessie Referral Hospital, South Wollo, Northeast Ethiopia.SAGE open medicine · 2021Article
- Admission Blood Glucose Is Associated With the 30-Days Mortality in Septic Patients: A Retrospective Cohort Study.Frontiers in medicine · 2021Article
- Native Valve Endocarditis due to Staphylococcus warneri Developing in a Patient with Type 1 Diabetes.Internal medicine (Tokyo, Japan) · 2020Article
- Diabetes and the Risk of Infection: A National Cohort Study.Diabetes & metabolism journal · 2019Article
- Impact of prior statin use on mortality in patients with type 2 diabetes mellitus and bloodstream infection.The Journal of international medical research · 2019Observational
- Hospital outcomes and cumulative burden from complications in type 2 diabetic sepsis patients: a cohort study using administrative and hospital-based databases.Therapeutic advances in endocrinology and metabolism · 2019Article
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Authors and funding
7 authors.
Funding
Abstract
Background: Epidemiologic and experimental evidence suggests that individuals with diabetes are at increased risk of infection. We sought to examine the association of diabetes and insulin therapy with hospitalization for infection and 28-day mortality. Methods: We performed a prospective cohort study using data from 30 239 community-dwelling participants aged ≥45 years enrolled in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. We defined diabetes as a fasting glucose level ≥126 mg/L (or ≥200 mg/L for those not fasting), the use of insulin or oral hypoglycemic agents, or self-reported history. We identified infection-related hospitalizations over the years 2003–2012. We fit Cox proportional hazards models to assess the association of diabetes with hazard rates of infection and logistic regression models for 28-day mortality. Results: Among 29 683 patients from the REGARDS study with complete follow-up, 7375 had diabetes. Over a median follow-up period of 6.5 years, we identified 2593 first and 3411 total infection hospitalizations. In adjusted analyses, participants with diabetes had an increased hazard of infection (hazard ratio, 1.50; 95% confidence interval [CI], 1.37–1.64) compared with those without diabetes. Participants with diabetes hospitalized for infection did not have an increased odds of death within 28 days (odds ratio, 0.94; 95% CI, .67–1.32). Participants receiving insulin therapy had greater hazard of infection (hazard ratio, 2.18; 95% CI, 1.90–2.51) but no increased odds of mortality (odd ratio, 1.07; 95% CI, .67–1.71). Conclusions: Diabetes is associated with increased risk of hospitalization for infection. However, we did not find an association with 28-day mortality. Insulin therapy conferred an even greater risk of hospitalization, without increased mortality.
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