Evidence map›Paper›PMID 28174756›Full record

ReviewCellular and molecular gastroenterology and hepatology2017

Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive

Ali Shawki, Declan F McCole

Open access · goldAbstract readReview
In one paragraph

Review in Cellular and molecular gastroenterology and hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Gut microbiota in health and disease.Molecular biomedicine · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Veterinary sciences · 2026
    Article
  10. Review
  11. Managing Acute Severe Ulcerative Colitis in 2025 and Beyond.Current gastroenterology reports · 2026
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ali ShawkiDivision of Biomedical Sciences, University of California Riverside, Riverside, California.
Declan F McColeDivision of Biomedical Sciences, University of California Riverside, Riverside, California.
University of California, Riverside · US

Funding

A NOVEL ROLE FOR PTPN2 IN INTESTINAL EPITHELIAL BARRIER REGULATIONR01DK091281 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Declan McCole · 2012 to 2026
$5.5M
NIDDK NIH HHS R01 DK091281
6 · The paper itself

Abstract

Pathobiont expansion, such as that of adherent-invasive

Indexed as

AIEC, adherent-invasive Escherichia coliAJ, adherens junctionAJC, apical junctional complexBP, bacterial peptidoglycansCD, Crohn’s diseaseCEACAM6, carcinoembryonic antigen–related cell-adhesion moleculeIBD, inflammatory bowel diseaseIEC, intestinal epithelial cellIFN, interferonIL, interleukinInflammatory Bowel DiseaseIntestinal PermeabilityJAM-A, junctional adhesion molecule-ALPF, long polar fimbriaeMLCK, myosin light chain kinaseMLC, myosin light chainNF-κB, nuclear factor-κBNOD2, nucleotide-binding oligomerization domain 2PDZ, PSD95-DlgA-zonula occludens-1 homology domainTight JunctionsTJ, tight junctionTNF, tumor necrosis factorUC, ulcerative colitisZO, zonula occludens

Identifiers

PMID28174756
PMCPMC5247418
OpenAlexW2551464444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.