Evidence map›Paper›PMID 28174597›Full record

Observational studyWorld journal of emergency surgery : WJES2017

CD4 + CD25 + CD127 high cells as a negative predictor of multiple organ failure in acute pancreatitis.

Wei Wang, He-Ping Xiang, Hui-Ping Wang, Li-Xin Zhu, Xiao-Ping Geng

2 registry-linked trialsOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in World journal of emergency surgery : WJES, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03937323 completednot on this mapstarted 2019, after this paper: background citation

Immun Parameters and Flow Cytometry at Pancreatitis Patients

Typeobservational_patient_registrySponsorIstanbul Training and Research HospitalRan2019 to 2020Enrolled80ConditionsPancreatitis, Immune SuppressionArmsBlood lymphocyte subtypes and serum cytokines
NCT04502940 completednot on this mapstarted 2020, after this paper: background citation

Can we Measure Pancreatitis Severity With Flow Cytometry?

TypeobservationalSponsorIstanbul Training and Research HospitalRan2020 to 2021Enrolled53ConditionsPancreatitis, Lymphocytic Infiltrate, Immune System DiseasesArmsFlow Cytometric analysis
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis.Frontiers in cellular and infection microbiology · 2020
    Review
  13. Review
  14. Level of serum soluble Tim-3 expression in early-phase acute pancreatitis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei WangDepartment of Emergency Surgery, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601 Anhui Province People's Republic of China.
He-Ping XiangDepartment of Emergency Surgery, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601 Anhui Province People's Republic of China.
Hui-Ping WangHematology department, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601 Anhui Province People's Republic of China.
Li-Xin ZhuCentral lab of the First Affiliated Hospital of Anhui Medical University, Hefei, 230022 Anhui Province People's Republic of China.
Xiao-Ping GengDepartment of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601 Anhui Province People's Republic of China.
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been suggested that severity of the immune response induced by immune cells is associated with morbidity and mortality from acute pancreatitis. The authors investigated and evaluated the relationship between distinct peripheral lymphocyte subsets at admission and clinical outcome prior to hospital discharge so as to find a predictor to the prognosis of acute pancreatitis in lymphocyte profile.

methodsLymphocyte subsets in admission peripheral venous blood were tested through flow cytometry on 48 patients with acute pancreatitis. Clinical data was recorded as well. The primary observational outcomes were multiple organ failure (MOF) and infection.

resultsThere was a significant difference in natural killer cells between two subgroups sorted by the presence or absence of infection (25.5 ± 4.47 [95% CI 14.4, 36.6]

conclusionCD4 + CD25 + CD127

Indexed as

Decision Support TechniquesAcute DiseaseAdultAgedAPACHEFemaleFlow CytometryHumansLogistic ModelsLymphocyte CountLymphocytesMaleMiddle AgedOrgan Dysfunction ScoresPancreatitisPrognosisAcute pancreatitisCD4 + CD25 + CD127high cellMultiple organ failureNatural killer cellsPrognosisRegulatory T cell

Identifiers

PMID28174597
PMCPMC5290669
OpenAlexW2585745459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.