ReviewFrontiers in physiology2016
A Concert between Biology and Biomechanics: The Influence of the Mechanical Environment on Bone Healing.
Review in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 181 citations in OpenAlex.
- Smart crutch tipsEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Trial
- Early Postoperative Effects of Mechanical Versus Manual Femoral Canal Opening During Proximal Femoral Nail Antirotation Fixation of Pertrochanteric Femoral Fractures.Medicina (Kaunas, Lithuania) · 2026Trial
- Fracture nonunion: classification, evaluation and management strategies-a structured approach for higher orthopaedic examinations.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Review
- Piezo channels in physical field therapy: From mechanotransduction mechanisms to bioelectromagnetic modulation and biomedical applications.Mechanobiology in medicine · 2026Review
- Instrumentalized 3D printed scaffolds enable bone regeneration and fracture healing monitoring in critical size bone defects.APL bioengineering · 2026Article
- The Mechano-Genomic Frontier: Orchestrating Nuclear Deformation for Craniomaxillofacial Bone Regeneration.Journal of clinical medicine · 2026Review
- The role and therapeutic potential of vitamins in fracture healing.Nutrition journal · 2026Review
- AI-planned and robotic-assisted pedicle screw placement improves accuracy and reduces loosening in lumbar fusion for patients with low bone mass: a multicenter study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- RibXcar with Dots Point Technique: The Science of Fracture as a Safety Principle.Plastic and reconstructive surgery. Global open · 2026Article
- Application of axial load-share ratio testing technology in the bone transport treatment of large segmental tibial bone defects.BMC musculoskeletal disorders · 2026Article
- Rate of fibular non-union in patients with tibial shaft fractures: a retrospective cohort study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review).International journal of molecular medicine · 2026Review
- A spatiotemporal atlas of senescence-associated secretory phenotype in fracture healing: stage-dependent mechanisms and therapeutic windows.Inflammation and regeneration · 2026Review
- A Real-Time Mechanical Information Acquisition System and Finite Element Prediction Method for Limb Lengthening: A Pilot In Vivo Study.Sensors (Basel, Switzerland) · 2026Article
- Refining predictive biomechanics for orthopedic healing.Journal of orthopaedic translation · 2026Article
- Author's reply to the letters regarding "Preclinical validation of finite element models for predicting in vivo residual plate bending using continuous implant sensor data".Journal of orthopaedic translation · 2026Article
- Fibroblast-Derived ECM as a Donor-Specific Pro-Osteogenic Coating Surpassing ASC- and Osteoblast-Derived ECM.Journal of functional biomaterials · 2026Article
- Revisiting bone healing strategies: the potential of reverse dynamization in veterinary orthopedics.Frontiers in veterinary science · 2026Review
- Porous tantalum cage loaded with CGF promotes interbody fusion in a rat XLIF model.Scientific reports · 2025Article
- Subject-specific multivariate modeling for regenerative rehabilitation of bone healing.APL bioengineering · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to achieve consistent and predictable fracture healing, a broad spectrum of growth factors are required to interact with one another in a highly organized response. Critically important, the mechanical environment around the fracture site will significantly influence the way bone heals, or if it heals at all. The role of the various biological factors, the timing, and spatial relationship of their introduction, and how the mechanical environment orchestrates this activity, are all crucial aspects to consider. This review will synthesize decades of work and the acquired knowledge that has been used to develop new treatments and technologies for the regeneration and healing of bone. Moreover, it will discuss the current state of the art in experimental and clinical studies concerning the application of these mechano-biological principles to enhance bone healing, by controlling the mechanical environment under which bone regeneration takes place. This includes everything from the basic principles of fracture healing, to the influence of mechanical forces on bone regeneration, and how this knowledge has influenced current clinical practice. Finally, it will examine the efforts now being made for the integration of this research together with the findings of complementary studies in biology, tissue engineering, and regenerative medicine. By bringing together these diverse disciplines in a cohesive manner, the potential exists to enhance fracture healing and ultimately improve clinical outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.