ArticleFrontiers in aging neuroscience2017
Reward Dependent Invigoration Relates to Theta Oscillations and Is Predicted by Dopaminergic Midbrain Integrity in Healthy Elderly.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Curiosity and surprise differentially affect memory depending on age.Scientific reports · 2025Article
- Differential effects of expectancy on memory formation in young and older adults.Human brain mapping · 2023Article
- Cognitive training, but not EEG-neurofeedback, improves working memory in healthy volunteers.Brain communications · 2023Article
- Ventral tegmental area integrity measured with high-resolution 7-Tesla MRI relates to motivation across depression and anxiety diagnoses.NeuroImage · 2022Article
- Still Wanting to Win: Reward System Stability in Healthy Aging.Frontiers in aging neuroscience · 2022Article
- Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning.Scientific reports · 2021Article
- Cortical Patterns of Pleasurable Musical Chills Revealed by High-Density EEG.Frontiers in neuroscience · 2020Article
- Dopamine Related Genes Differentially Affect Declarative Long-Term Memory in Healthy Humans.Frontiers in behavioral neuroscience · 2020Article
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2 authors.
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Abstract
Motivation can have invigorating effects on behavior via dopaminergic neuromodulation. While this relationship has mainly been established in theoretical models and studies in younger subjects, the impact of structural declines of the dopaminergic system during healthy aging remains unclear. To investigate this issue, we used electroencephalography (EEG) in healthy young and elderly humans in a reward-learning paradigm. Specifically, scene images were initially encoded by combining them with cues predicting monetary reward (high vs. low reward). Subsequently, recognition memory for the scenes was tested. As a main finding, we can show that response times (RTs) during encoding were faster for high reward predicting images in the young but not elderly participants. This pattern was resembled in power changes in the theta-band (4-7 Hz). Importantly, analyses of structural MRI data revealed that individual reward-related differences in the elderlies' response time could be predicted by the structural integrity of the dopaminergic substantia nigra (SN; as measured by magnetization transfer (MT)). These findings suggest a close relationship between reward-based invigoration, theta oscillations and age-dependent changes of the dopaminergic system.
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