ArticleScientific reports2017
Identification and expression analysis of the apple (Malus × domestica) basic helix-loop-helix transcription factor family.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 67 citations in OpenAlex.
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- Untargeted metabolomic genome-wide association study reveals genetic and biochemical insights into polyphenols of apple fruit.Horticulture research · 2025Article
- Three bilberry bHLHs of subgroup IIIf play divergent roles in fruit anthocyanin and flavonoid biosynthesis.Scientific reports · 2025Article
- Genome- and Transcriptome-Wide Characterization and Expression Analyses of bHLH Transcription Factor Family Reveal Their Relevance to Salt Stress Response in Tomato.Plants (Basel, Switzerland) · 2025Article
- Whole-genome identification and functional analysis of grape bHLH transcription factors: new insights into the regulation of monoterpene biosynthesis.Frontiers in plant science · 2025Article
- Genome-wide identification and expression profiling of bHLH transcription factors associated with ferulic acid biosynthesis inFrontiers in plant science · 2025Article
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- Genome-wide identification and expression analysis of bHLH gene family revealed their potential roles in abiotic stress response, anthocyanin biosynthesis and trichome formation inFrontiers in plant science · 2024Article
- Genome-Wide Identification and Characterization of thePlants (Basel, Switzerland) · 2023Article
- Genome-Wide Analysis ofInternational journal of molecular sciences · 2023Article
- Genome-Wide Identification and Expression Analysis of the bHLH Transcription Factor Family in Wintersweet (International journal of molecular sciences · 2023Article
- Insights into the molecular mechanisms underlying responses of apple trees to abiotic stresses.Horticulture research · 2023Article
- Transcription FactorInternational journal of molecular sciences · 2023Article
- Comprehensive Analysis of bHLH Transcription Factors inInternational journal of molecular sciences · 2023Article
- RcbHLH59-RcPRs module enhances salinity stress tolerance by balancing NaHorticulture research · 2023Article
- Genome-Wide Identification and Expression Analysis of the bHLH Transcription Factor Family and Its Response to Abiotic Stress in Mongolian Oak (Current issues in molecular biology · 2023Article
- Genome-wide identification, characterization, and validation of the bHLH transcription factors in grass pea.Frontiers in genetics · 2023Article
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Corrections and comments
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Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basic helix-loop-helix (bHLH) proteins, which are characterized by a conserved bHLH domain, comprise one of the largest families of transcription factors in both plants and animals, and have been shown to have a wide range of biological functions. However, there have been very few studies of bHLH proteins from perennial tree species. We describe here the identification and characterization of 175 bHLH transcription factors from apple (Malus × domestica). Phylogenetic analysis of apple bHLH (MdbHLH) genes and their Arabidopsis thaliana (Arabidopsis) orthologs indicated that they can be classified into 23 subgroups. Moreover, integrated synteny analysis suggested that the large-scale expansion of the bHLH transcription factor family occurred before the divergence of apple and Arabidopsis. An analysis of the exon/intron structure and protein domains was conducted to suggest their functional roles. Finally, we observed that MdbHLH subgroup III and IV genes displayed diverse expression profiles in various organs, as well as in response to abiotic stresses and various hormone treatments. Taken together, these data provide new information regarding the composition and diversity of the apple bHLH transcription factor family that will provide a platform for future targeted functional characterization.
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