ArticleProceedings of the National Academy of Sciences of the United States of America2017
Low escape-rate genome safeguards with minimal molecular perturbation of
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Extrachromosomally co-encoded toxin-immunity pairs in yeast and their application potential.Applied microbiology and biotechnology · 2026Review
- Towards the development of a CRISPR-Cas9 based kill switch for Saccharomyces cerevisiae.Microbial cell factories · 2026Article
- Biocontainment efficacy redefined.Applied and environmental microbiology · 2025Article
- Secure biosystems design inApplied and environmental microbiology · 2025Article
- Engineering Saccharomyces cerevisiae for medical applications.Microbial cell factories · 2025Review
- Quadruplet codon decoding-based versatile genetic biocontainment system.Nucleic acids research · 2025Article
- Engineering stringent genetic biocontainment of yeast with a protein stability switch.Nature communications · 2024Article
- A bumpy road ahead for genetic biocontainment.Nature communications · 2024Article
- Rise of synthetic yeast: Charting courses to new applications.Cell genomics · 2023Article
- A robust yeast biocontainment system with two-layered regulation switch dependent on unnatural amino acid.Nature communications · 2023Article
- Review
- Peptide-Dependent Growth in Yeast via Fine-Tuned Peptide/GPCR-Activated Essential Gene Expression.Biochemistry · 2022Article
- A genome-scale yeast library with inducible expression of individual genes.Molecular systems biology · 2021Article
- Engineered fluoride sensitivity enables biocontainment and selection of genetically-modified yeasts.Nature communications · 2020Article
- Biosensing in Smart Engineered Probiotics.Biotechnology journal · 2020Review
- Controlling the Implementation of Transgenic Microbes: Are We Ready for What Synthetic Biology Has to Offer?Molecular cell · 2020Review
- Fail-safe genetic codes designed to intrinsically contain engineered organisms.Nucleic acids research · 2019Article
- Review
- A scalable peptide-GPCR language for engineering multicellular communication.Nature communications · 2018Article
- Next-generation biocontainment systems for engineered organisms.Nature chemical biology · 2018Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the use of synthetic biology both in industry and in academia grows, there is an increasing need to ensure biocontainment. There is growing interest in engineering bacterial- and yeast-based safeguard (SG) strains. First-generation SGs were based on metabolic auxotrophy; however, the risk of cross-feeding and the cost of growth-controlling nutrients led researchers to look for other avenues. Recent strategies include bacteria engineered to be dependent on nonnatural amino acids and yeast SG strains that have both transcriptional- and recombinational-based biocontainment. We describe improving yeast
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.