Evidence map›Paper›PMID 28174264›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Hippo signaling promotes JNK-dependent cell migration.

Xianjue Ma, Hongxiang Wang, Jiansong Ji, Wenyan Xu, Yihao Sun, Wenzhe Li, Xiaoping Zhang, Juxiang Chen, Lei Xue

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Drosophila as a Model for Metastasis.Advances in experimental medicine and biology · 2025
    Review
  6. Hippo effector, Yorkie, is a tumor suppressor in selectProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Article
  14. Emerging Roles of RNA-Binding Proteins in Neurodevelopment.Journal of developmental biology · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Amyotrophic Lateral Sclerosis Genes inInternational journal of molecular sciences · 2021
    Review
  20. Rox8 promotes microRNA-dependentProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Xianjue MaInstitute of Intervention Vessel, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai 200092, China; xianjue.ma@yale.edu zxpkxy@126.com juxiangchen.cz@gmail.com lei.xue@tongji.edu.cn.
Hongxiang WangDepartment of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Jiansong JiRadiology Department and Interventional Radiology Center, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang 323000, China.
Wenyan XuInstitute of Intervention Vessel, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Yihao SunInstitute of Intervention Vessel, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Wenzhe LiInstitute of Intervention Vessel, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Xiaoping ZhangInstitute of Intervention Vessel, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai 200092, China; xianjue.ma@yale.edu zxpkxy@126.com juxiangchen.cz@gmail.com lei.xue@tongji.edu.cn.
Juxiang ChenDepartment of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; xianjue.ma@yale.edu zxpkxy@126.com juxiangchen.cz@gmail.com lei.xue@tongji.edu.cn.
Lei XueInstitute of Intervention Vessel, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai 200092, China; xianjue.ma@yale.edu zxpkxy@126.com juxiangchen.cz@gmail.com lei.xue@tongji.edu.cn.
Tongji University · CNShanghai Changzheng Hospital · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overwhelming studies show that dysregulation of the Hippo pathway is positively correlated with cell proliferation, growth, and tumorigenesis. Paradoxically, the detailed molecular roles of the Hippo pathway in cell invasion remain debatable. Using a

Indexed as

Gene Expression Regulation, NeoplasticAdaptor Proteins, Signal TransducingAnimalsApoptosisCarcinogenesisCell Line, TumorCell MovementCell ProliferationDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsEpithelial-Mesenchymal TransitionGene Knockdown TechniquesHippo KinasesHumansIntracellular Signaling Peptides and ProteinsAdaptor Proteins, Signal Transducingbantam microRNA, DrosophilaDrosophila ProteinsHippo Kinaseshpo protein, DrosophilaIntracellular Signaling Peptides and ProteinsJNK Mitogen-Activated Protein KinasesMatrix Metalloproteinase 1MicroRNAsNuclear ProteinsPhosphoproteinsProtein Serine-Threonine KinasesRNA-Binding ProteinsRNA, Small InterferingRox8 protein, DrosophilaT-Cell Intracellular Antigen-1TIA1 protein, humanTrans-ActivatorsTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsYki protein, DrosophilaDrosophilaHippoJNKmigrationRox8

Identifiers

PMID28174264
PMCPMC5338425
OpenAlexW2587552204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.