Evidence map›Paper›PMID 28174243›Full record

ArticleDevelopment (Cambridge, England)2017

Efficient TALEN-mediated gene targeting of chicken primordial germ cells.

Lorna Taylor, Daniel F Carlson, Sunil Nandi, Adrian Sherman, Scott C Fahrenkrug, Michael J McGrew

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 136 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Manipulating primordial germ cells from chicken and other bird species.The Journal of reproduction and development · 2026
    Review
  8. Review
  9. Review
  10. The avian embryo as a time-honoured animal model in developmental, biomedical and agricultural research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lorna TaylorThe Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK.
Daniel F CarlsonRecombinetics Inc, 1246 University Avenue West, Suite 300, Saint Paul, MN 55104, USA.
Sunil NandiThe Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK.
Adrian ShermanThe Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK.
Scott C FahrenkrugRecombinetics Inc, 1246 University Avenue West, Suite 300, Saint Paul, MN 55104, USA.
Michael J McGrewThe Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK mike.mcgrew@roslin.ed.ac.uk.ORCID 0000-0001-8213-4632
Roslin Institute · GBRecombinetics (United States) · US

Funding

Biotechnology and Biological Sciences Research Council BB/J004219/1Biotechnology and Biological Sciences Research Council BB/J004316/1Biotechnology and Biological Sciences Research Council BBS/E/D/20320000
6 · The paper itself

Abstract

In this work we use TALE nucleases (TALENs) to target a reporter construct to the

Indexed as

Gene TargetingTranscription Activator-Like Effector NucleasesAllelesAnimalsAnimals, Genetically ModifiedChickensCrosses, GeneticDEAD-box RNA HelicasesFemaleGene DeletionGene Knockout TechniquesGerm CellsGreen Fluorescent ProteinsMaleMeiosisTransgenesDEAD-box RNA HelicasesGreen Fluorescent ProteinsTranscription Activator-Like Effector NucleasesAvianChickenDDX4Primordial germ cellTALENTransgenic knockout

Identifiers

PMID28174243
PMCPMC5374353
OpenAlexW2586599127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.