Evidence map›Paper›PMID 28174207›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Heparin-binding epidermal growth factor-like growth factor promotes neuroblastoma differentiation.

Angela L Gaviglio, Erik H Knelson, Gerard C Blobe

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Heparan Sulfate Proteoglycan Signaling in Tumor Microenvironment.International journal of molecular sciences · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Angela L GaviglioDepartment of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA.
Erik H KnelsonDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; and.
Gerard C BlobeDepartment of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA; gerard.blobe@duke.edu.
Brigham and Women's Hospital · USDuke Medical Center · USDuke University · US

Funding

Epigenetic Regulation of Neuroblast DifferentiationF31CA192558 · NCI · DUKE UNIVERSITY · PI GAVIGLIO, ANGELA · 2015 to 2016
$60k
NCI NIH HHS F31 CA192558
6 · The paper itself

Abstract

High-risk neuroblastoma is characterized by undifferentiated neuroblasts and low schwannian stroma content. The tumor stroma contributes to the suppression of tumor growth by releasing soluble factors that promote neuroblast differentiation. Here we identify heparin-binding epidermal growth factor-like growth factor (HBEGF) as a potent prodifferentiating factor in neuroblastoma.

Indexed as

Cell DifferentiationCell Line, TumorErbB ReceptorsHeparan Sulfate ProteoglycansHeparin-binding EGF-like Growth FactorHumansNeuroblastomaUp-RegulationErbB ReceptorsHBEGF protein, humanHeparan Sulfate ProteoglycansHeparin-binding EGF-like Growth FactorcancerHBEGFheparan sulfatesignalingstroma

Identifiers

PMID28174207
PMCPMC5388552
OpenAlexW2587614615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.