Evidence map›Paper›PMID 28174068›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017

Patient and caregiver reactions to clinical amyloid imaging.

Joshua D Grill, Chelsea G Cox, Sarah Kremen, Mario F Mendez, Edmond Teng, Jill Shapira, John M Ringman, Liana G Apostolova

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Outcomes of clinical utility in amyloid-PET studies: state of art and future perspectives.European journal of nuclear medicine and molecular imaging · 2021
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Facing the new diagnostic and treatment options of Alzheimer's disease: The necessity of informed consent.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Article
  10. Counseling and disclosure practices in predictive Alzheimer's disease diagnostics: A scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  11. Psychological outcomes of dementia risk estimation in MCI patients: Results from the PreDADQoL project.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Joshua D GrillInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA. Electronic address: jgrill@uci.edu.
Chelsea G CoxInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Sarah KremenDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Mario F MendezDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA; Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA.
Edmond TengDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA; Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA.
Jill ShapiraDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA; Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA.
John M RingmanDepartment of Neurology, University of Southern California, Los Angeles, CA, USA.
Liana G ApostolovaDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA; Alzheimer's Disease Center, University of Indiana, Indianapolis, IN, USA; Department of Neurology, University of Indiana, Indianapolis, IN, USA; Department of Radiology, University of Indiana, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, University of Indiana, Indianapolis, IN, USA.
University of California, Irvine · USUniversity of California, Los Angeles · USVA Greater Los Angeles Healthcare System · USIndiana University – Purdue University Indianapolis · USUniversity of Southern California · US

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CUMMINGS, JEFFREY L. · 1999 to 2014
$25.9M
NIA NIH HHS P50 AG016570NIA NIH HHS P50 AG016573
6 · The paper itself

Abstract

introductionAmyloid imaging is a tool that has recently become available to dementia specialists evaluating patients with possible Alzheimer's disease. Studies have assessed the impact of amyloid imaging on diagnostic and treatment decisions, but patient and family perspectives have received less attention.

methodsTo examine how amyloid imaging affects the diagnostic experience of patients and families, we interviewed members of 26 patient-caregiver dyads with whom a neurologist discussed the option of amyloid positron emission tomography.

resultsMost participants who chose to undergo amyloid imaging would choose to do so again. Regardless of the scan outcome, patients and caregivers commonly expressed relief on learning the scan results. Some participants expressed expectations that were beyond scan capabilities. DISCUSSION: Amyloid imaging may provide information that patients and their families find useful. Clinicians must set correct expectations and ensure that families understand the limitations of amyloid imaging.

Indexed as

Patient SatisfactionAgedAged, 80 and overAlzheimer DiseaseAmyloidAniline CompoundsBrainCaregiversCognitive DysfunctionEthylene GlycolsFemaleHumansInterviews as TopicMaleMemory DisordersMental Status and Dementia TestsAmyloidAniline CompoundsEthylene GlycolsflorbetapirRadiopharmaceuticalsAmyloid imagingBiomarkerDiagnosisEncounterPositron emission tomography

Identifiers

PMID28174068
PMCPMC5544590
OpenAlexW2585064771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.