ArticleThe journal of allergy and clinical immunology. In practice
Antibiotic Use in Early Life, Rural Residence, and Allergic Diseases in Argentinean Children.
Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between early-life antibiotic exposure and gut microbiome alterations linked to allergic diseases in children: a systematic review.European journal of medical research · 2025Pooled it
- Cesarean section and the risk of allergic rhinitis in children: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence.Clinical reviews in allergy & immunology · 2023Pooled it
- Gut microbiome dynamics in acute infectious diarrhea: A conceptual framework from acute dysbiosis toward precision restoration (Review).Experimental and therapeutic medicine · 2026Review
- Asthma in the Americas: An Update: A Joint Perspective from the Brazilian Thoracic Society, Canadian Thoracic Society, Latin American Thoracic Society, and American Thoracic Society.Annals of the American Thoracic Society · 2022Review
- Meta-analysis of early-life antibiotic use and allergic rhinitis.Open medicine (Warsaw, Poland) · 2022Article
- Association of infant antibiotic exposure and risk of childhood asthma: A meta-analysis.The World Allergy Organization journal · 2021Article
- Integrated Metagenomic and Transcriptomic Analyses Reveal the Dietary Dependent Recovery of Host Metabolism From Antibiotic Exposure.Frontiers in cell and developmental biology · 2021Article
- Important Role of Immunological Responses to Environmental Exposure in the Development of Allergic Asthma.Allergy, asthma & immunology research · 2020Review
- Microbiota and Food Allergy.Clinical reviews in allergy & immunology · 2019Review
- Antibiotic overuse and allergy-related diseases: an epidemiological cross-sectional study in the grasslands of Northern China.Therapeutics and clinical risk management · 2019Article
- Inherited nongenetic influences on the gut microbiome and immune system.Birth defects research · 2018Review
- Is childhood wheeze and asthma in Latin America associated with poor hygiene and infection? A systematic review.BMJ open respiratory research · 2018Article
- Investigation of possible risk factors in the development of seasonal allergic conjunctivitis.International journal of ophthalmology · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundLittle is known about differential effects of antibiotic use on allergic diseases in rural versus urban environments.
objectiveTo examine whether area of residence in the first year of life modifies the relation between antibiotic use in early life and allergic diseases during childhood.
methodsCross-sectional study of allergic diseases in 1517 children (ages 6-7 years) attending 101 schools in urban and rural areas of San Francisco (Córdoba, Argentina). Current asthma, wheeze, and allergic rhinoconjunctivitis were defined on the basis of responses to a validated questionnaire from the International Study of Asthma and Allergies in Childhood. Multivariate logistic regression was used for the analysis of antibiotic use and allergic diseases.
resultsAfter adjustment for paracetamol use, bronchiolitis, and other covariates, antibiotic use in the first year of life was associated with increased odds of current wheeze (odds ratio [OR], 1.8; 95% CI, 1.3-2.6) and allergic rhinoconjunctivitis (OR, 1.9; 95% CI, 1.3-2.7). After stratification by area of residence, antibiotic use was associated with current wheeze (OR, 2.4; 95% CI, 1.5-4.0) and allergic rhinoconjunctivitis (OR, 2.1; 95% CI, 1.3-3.4) among children who lived in an urban area in their first year of life, but not among those who lived in a rural area in their first year of life.
conclusionsEarly-life antibiotic use is associated with current wheeze and allergic rhinoconjunctivitis in Argentinean children who lived in urban areas during their first year of life. Exposure to a rural environment early in life may protect against the adverse effects of antibiotics on atopic diseases in children.
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