Evidence map›Paper›PMID 28173973›Full record

ArticleParkinsonism & related disorders2017

Personality and addictive behaviours in early Parkinson's disease and REM sleep behaviour disorder.

Fahd Baig, Michael A Lawton, Michal Rolinski, Claudio Ruffmann, Johannes C Klein, Kannan Nithi, David Okai, Yoav Ben-Shlomo, Michele T M Hu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

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  13. Impulse Control Disorders in REM Sleep Behavior Disorder.Current treatment options in neurology · 2019
    Review
  14. Impulse control disorders in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fahd BaigOxford Parkinson's Disease Centre, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Michael A LawtonSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Michal RolinskiOxford Parkinson's Disease Centre, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Claudio RuffmannOxford Parkinson's Disease Centre, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Johannes C KleinOxford Parkinson's Disease Centre, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Kannan NithiOxford Parkinson's Disease Centre, University of Oxford, Oxford, UK; Department of Neurology, Northampton General Hospital NHS Trust, Northampton, UK.
David OkaiPsychological Medicine Service, Oxford University Hospitals NHS Trust, Oxford, UK.
Yoav Ben-ShlomoOxford Parkinson's Disease Centre, University of Oxford, Oxford, UK; School of Social and Community Medicine, University of Bristol, Bristol, UK.
Michele T M HuOxford Parkinson's Disease Centre, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: michele.hu@ndcn.ox.ac.uk.
University of Oxford · GBUniversity of Bristol · GBOxford University Hospitals NHS Trust · GB

Funding

Department of HealthParkinson's UK J-0901
6 · The paper itself

Abstract

introductionChanges in personality have been described in Parkinson's disease (PD), with suggestion that those with established disease tend to be risk averse with a disinclination for addictive behaviour. However, little is known about the earliest and prodromal stages. Personality and its relationship with addictive behaviours can help answer important questions about the mechanisms underlying PD and addiction.

methods941 population-ascertained PD subjects within 3.5 years of diagnosis, 128 patients with rapid eye movement sleep behaviour disorder (RBD) and 292 control subjects were fully characterised for motor symptoms, non-motor symptoms and across the following 5 personality domains: 1) neuroticism 2) extraversion 3) conscientiousness 4) agreeableness 5) openness using the Big Five Inventory.

resultsPatients with early PD were more neurotic (p < 0.001), less extraverted (p < 0.001) and less open than controls (p < 0.001). RBD subjects showed the same pattern of being more neurotic (p < 0.001), less extraverted (p = 0.03) and less open (p < 0.001). PD patients had smoked less (p = 0.02) and drunk less alcohol (p = 0.03) than controls, but caffeine beverage consumption was similar. Being more extraverted (p < 0.001), more open (p < 0.001), and less neurotic (p < 0.001) predicted higher alcohol use, while being more extravert (p = 0.007) and less agreeable (p < 0.001) was associated with smoking more.

conclusionsA similar pattern of personality changes is seen in PD and RBD compared to a control population. Personality characteristics were associated with addictive behaviours, suggestive of a common link, but the lower rates of addictive behaviours before and after the onset of motor symptoms in PD persisted after accounting for personality.

Indexed as

PersonalityAdultAgedAged, 80 and overBehavior, AddictiveFemaleHumansMaleMiddle AgedParkinson DiseasePersonality AssessmentPersonality DisordersREM Sleep Behavior DisorderSeverity of Illness IndexAddictionParkinson's diseasePersonalityREM sleep behaviour disorderSmoking

Identifiers

PMID28173973
PMCPMC5380654
OpenAlexW2583899953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.