ArticleBreast cancer research : BCR2017
Childhood body size and pubertal timing in relation to adult mammographic density phenotype.
Article in Breast cancer research : BCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women.Cancer causes & control : CCC · 2018Trial
- Early thelarche, reproductive hormones, and MRI-based breast density: a prospective study in China.Breast cancer research : BCR · 2025Article
- Lifecourse Growth and Development Determinants of Mammographic Density in Black Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Association between breastfeeding, mammographic density, and breast cancer risk: a review.International breastfeeding journal · 2024Review
- PFAS Levels, Early Life Factors, and Mammographic Breast Density in Premenopausal Women.Environmental health perspectives · 2024Article
- Associations of Early-Life and Adult Anthropometric Measures with the Expression of Stem Cell Markers CD44, CD24, and ALDH1A1 in Women with Benign Breast Biopsies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- The Prospective Association between Early Life Growth and Breast Density in Young Adult Women.Cancers · 2024Article
- Mammographic density mediates the protective effect of early-life body size on breast cancer risk.Nature communications · 2024Article
- Biological Basis of Breast Cancer-Related Disparities in Precision Oncology Era.International journal of molecular sciences · 2024Review
- The Associations between Intakes of One-Carbon Metabolism-Related Vitamins and Breast Density among Young Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium.Breast cancer research : BCR · 2023Article
- Childhood adiposity, serum metabolites and breast density in young women.Breast cancer research : BCR · 2022Article
- Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls.Environment international · 2022Article
- The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.Breast cancer research : BCR · 2022Article
- Associations between infant growth and pubertal onset timing in a multiethnic prospective cohort of girls.BMC pediatrics · 2022Article
- Early-Life and Adult Adiposity, Adult Height, and Benign Breast Tissue Composition.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Pubertal timing and breast cancer risk in the Sister Study cohort.Breast cancer research : BCR · 2020Article
- Pubertal timing and breast density in young women: a prospective cohort study.Breast cancer research : BCR · 2019Article
- Do Birth Weight and Weight Gain During Infancy and Early Childhood Explain Variation in Mammographic Density in Women in Midlife? Results From Cohort and Sibling Analyses.American journal of epidemiology · 2019Article
- Childhood body size and midlife mammographic breast density in foreign-born and U.S.-born women in New York City.Annals of epidemiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn earlier age at onset of breast development and longer time between pubertal stages has been implicated in breast cancer risk. It is not clear whether associations of breast cancer risk with puberty or predictors of onset of puberty, such as weight and height, are mediated via mammographic density, an important risk factor for breast cancer.
methodsWe investigated whether childhood body size and pubertal timing and tempo, collected by questionnaire, are associated with percentage and absolute area mammographic density at ages 47-73 years in 1105 women recruited to a prospective study.
resultsAfter controlling for adult adiposity, weight at ages 7 and 11 years was strongly significantly inversely associated with percentage and absolute dense area (p trend <0.001), and positively associated with absolute non-dense area. Greater height at age 7, but not age 11, was associated with lower percentage density (p trend = 0.016). Later age at menarche and age at when regular periods were established was associated with increased density, but additional adjustment for childhood weight attenuated the association. A longer interval between thelarche and menarche, and between thelarche and regular periods, was associated with increased dense area, even after adjusting for childhood weight (p trend = 0.013 and 0.028, respectively), and was independent of age at pubertal onset.
conclusionsGreater prepubertal weight and earlier pubertal onset are associated with lower adult breast density, but age at pubertal onset does not appear to have an independent effect on adult density after controlling for childhood adiposity. A possible effect of pubertal tempo on density needs further investigation.
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