Evidence map›Paper›PMID 28173831›Full record

ArticleStem cell research & therapy2017

Immunoselected STRO-3

Anwar Abdalmula, Laura M Dooley, Claire Kaufman, Elizabeth A Washington, Jacqueline V House, Barbara A Blacklaws, Peter Ghosh, Silviu Itescu, Simon R Bailey, Wayne G Kimpton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Anwar AbdalmulaFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, 5010, Australia.
Laura M DooleyFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, 5010, Australia.
Claire KaufmanFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, 5010, Australia.
Elizabeth A WashingtonFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, 5010, Australia.
Jacqueline V HouseFlorey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia.
Barbara A BlacklawsDepartment of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.
Peter GhoshMesoblast Ltd, 55 Collins Street, Melbourne, VIC, 3000, Australia.
Silviu ItescuMesoblast Ltd, 55 Collins Street, Melbourne, VIC, 3000, Australia.
Simon R BaileyFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, 5010, Australia. bais@unimelb.edu.au.
Wayne G KimptonFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, 5010, Australia.
University of Melbourne · AUFlorey Institute of Neuroscience and Mental Health · AUUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study was to investigate the therapeutic efficacy of intravenously administered immunoselected STRO-3 + mesenchymal precursor cells (MPCs) on clinical scores, joint pathology and cytokine production in an ovine model of monoarthritis.

methodsMonoarthritis was established in 16 adult merino sheep by administration of bovine type II collagen into the left hock joint following initial sensitization to this antigen. After 24 h, sheep were administered either 150 million allogeneic ovine MPCs (n = 8) or saline (n = 8) intravenously (IV). Lameness, joint swelling and pain were monitored and blood samples for leukocytes and cytokine levels were collected at intervals following arthritis induction. Animals were necropsied 14 days after arthritis induction and gross and histopathological evaluations were undertaken on tissues from the arthritic (left) and contralateral (right) joints.

resultsMPC-treated sheep demonstrated significantly reduced clinical signs of lameness, joint pain and swelling compared with saline controls. They also showed decreased cartilage erosions, synovial stromal cell activation and angiogenesis. This was accompanied by decreased infiltration of the synovial tissues by CD4

conclusionsThe results of this study have demonstrated the capacity of IV-administered MPCs to mitigate the clinical signs and some of the inflammatory mediators responsible for joint tissue destruction in a large animal model of monoarthritis.

Indexed as

Mesenchymal Stem Cell TransplantationActivinsAnimalsAntigens, SurfaceArthritis, ExperimentalArthritis, RheumatoidCD4-Positive T-LymphocytesCell DifferentiationCell MovementCollagen Type IIDisease Models, AnimalFemaleGene ExpressionInterferon-gammaInterleukin-10Interleukin-17activin AActivinsAntigens, SurfaceCollagen Type IIInterferon-gammaInterleukin-10Interleukin-17Animal modelCollagen-induced arthritisMesenchymal stem cellsNeutrophils

Identifiers

PMID28173831
PMCPMC5297153
OpenAlexW2587112212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.