Evidence map›Paper›PMID 28172715›Full record

ReviewEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2017

Atrial high-rate episodes and stroke prevention.

A John Camm, Emmanuel Simantirakis, Andreas Goette, Gregory Y H Lip, Panos Vardas, Melanie Calvert, Gregory Chlouverakis, Hans-Christoph Diener, Paulus Kirchhof

Open access · hybridAbstract readReview
In one paragraph

Review in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 103 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Observational
  7. Article
  8. The Year in Cardiology-Practice Changing Trials from European Society of Cardiology Congress 2023.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025
    Review
  9. Article
  10. Screening and diagnosis of atrial fibrillation using wearable devices.The Korean journal of internal medicine · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. The influence of atrial high-rate episodes on stroke and cardiovascular death: an update.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  17. Atrial high-rate episodes intensify RScientific reports · 2023
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

A John CammDepartment of Clinical Cardiology, St George's University of London, London, UK.
Emmanuel SimantirakisCardiology Department, Heraklion University Hospital, Voutes, Heraklion, Crete, Greece.
Andreas GoetteChief of Cardiology and Intensive Care Medicine, St. Vincenz-Hospital Paderborn, Paderborn, Germany.
Gregory Y H LipUniversity of Birmingham, Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
Panos VardasCardiology Department, Heraklion University Hospital, Voutes, Heraklion, Crete, Greece.
Melanie CalvertInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Gregory ChlouverakisBiostatistics Lab, School of Medicine, University of Crete, Crete, Greece.
Hans-Christoph DienerDepartment of Neurology, University Hospital Essen, Essen, Germany.
Paulus KirchhofInstitute of Cardiovascular Sciences, University of Birmingham, SWBH and UHB NHS Trusts, Birmingham, UK
University Hospital of Heraklion · GRUniversity of Birmingham · GBBirmingham City Hospital · GBBrüderkrankenhaus St. Josef Paderborn · DEEssen University Hospital · DESt George's, University of London · GBUniversity of Crete · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the benefit of oral anticoagulants (OACs) for stroke prevention in patients with atrial fibrillation (AF) is well established, it is not known whether oral anticoagulation is indicated in patients with atrial high-rate episodes (AHRE) recorded on a cardiac implantable electronic device, sometimes also called subclinical AF, and lasting for at least 6 min in the absence of clinically diagnosed AF. Clinical evidence has shown that short episodes of rapid atrial tachycarrhythmias are often detected in patients presenting with stroke and transient ischaemic attack. Patients with AHRE have a higher likelihood of suffering from subsequent strokes, but their stroke rate seems lower than in patients with diagnosed AF, and not all AHRE episodes correspond to AF. The prognostic and pathological significance of AHRE is not yet fully understood. Clinical trials of OAC therapy are being conducted to determine whether therapeutic intervention would be beneficial to patients experiencing AHRE in terms of reducing the risk of stroke.

Indexed as

AnticoagulantsAtrial FibrillationCardiac Resynchronization Therapy DevicesDefibrillators, ImplantableHumansStrokeAnticoagulantsAnticoagulationAtrial fibrillationAtrial high-rate episodesCardiovascular implantable electronic devicesParoxysmal atrial fibrillationStrokeSubclinical atrial fibrillationThromboembolic risk

Identifiers

PMID28172715
PMCPMC5400077
OpenAlexW2528951665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.