ArticleDevelopmental cell2017
Centrosome Amplification and Cancer: A Question of Sufficiency.
Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Microtubule-Associated Proteins: From Dynamic Regulation of Microtubules to Cellular Architecture.Cells · 2026Review
- CenSegNet: a generalist high-throughput deep learning framework for centrosome phenotyping at spatial and single-cell resolution in heterogeneous tissues.Nature communications · 2026Article
- McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation.EMBO reports · 2026Article
- KIFC1 Overexpression Promotes Pancreatic Carcinoma Progression via Stabilising BUB1B.Journal of cellular and molecular medicine · 2025Article
- Review
- Developmental and tissue-specific roles of mammalian centrosomes.The FEBS journal · 2025Review
- Molecular landscape and functional characterization of centrosome amplification in ovarian cancer.Nature communications · 2023Article
- The cell cycle, cancer development and therapy.Molecular biology reports · 2022Review
- Proteins implicated in muscular dystrophy and cancer are functional constituents of the centrosome.Life science alliance · 2022Article
- A catalog of numerical centrosome defects in epithelial ovarian cancers.EMBO molecular medicine · 2022Article
- Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12.Communications biology · 2021Article
- Multifaceted roles of centrosomes in development, health, and disease.Journal of molecular cell biology · 2021Review
- Generation and Fates of Supernumerary Centrioles in Dividing Cells.Molecules and cells · 2021Review
- The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels.Journal of cell science · 2021Article
- Article
- Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability.Biomolecules · 2019Review
- Cryo-Electron Tomography and Proteomics studies of centrosomes from differentiated quiescent thymocytes.Scientific reports · 2019Article
- Structural centrosome aberrations promote non-cell-autonomous invasiveness.The EMBO journal · 2018Article
- Engaging Anaphase Catastrophe Mechanisms to Eradicate Aneuploid Cancers.Molecular cancer therapeutics · 2018Review
- Cyclin A2 regulates symmetrical mitotic spindle formation and centrosome amplification in human colon cancer cells.American journal of translational research · 2018Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Centrosome amplification is a common feature of many types of cancer, but whether it is a cause or consequence is hotly debated. In this issue of Developmental Cell, Levine et al. (2017) provide strong evidence that centrosome amplification is sufficient to initiate tumorigenesis in a mouse model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.