Evidence map›Paper›PMID 28170439›Full record

ArticlePloS one2017

The association between environmental exposures during childhood and the subsequent development of Crohn's disease: A score analysis approach.

Victor Tinashe Sabe, Abigail Raffner Basson, Esme Jordaan, Mikateko Mazinu

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Victor Tinashe SabeMedical BioScience Department, University of the Western Cape, Bellville, Western Cape, South Africa.ORCID http://orcid.org/0000-0001-7294-9352
Abigail Raffner BassonMedical BioScience Department, University of the Western Cape, Bellville, Western Cape, South Africa.
Esme JordaanBiostatistics Unit, Medical Research Council of South Africa, Parow, Western Cape, South Africa.
Mikateko MazinuBiostatistics Unit, Medical Research Council of South Africa, Parow, Western Cape, South Africa and the Statistics and Population Studies Department, University of the Western Cape, Bellville, Western Cape, South Africa.
University of the Western Cape · ZACase Western Reserve University · USSouth African Medical Research Council · ZA

Funding

The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6M
Combined Training Program in Digestive Disease SciencesT32DK083251 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI COMINELLI, FABIO, FIOCCHI, CLAUDIO · 2010 to 2025
$3.6M
NIDDK NIH HHS P30 DK097948NIDDK NIH HHS T32 DK083251
6 · The paper itself

Abstract

backgroundEnvironmental factors during childhood are thought to play a role in the aetiology of Crohn's Disease (CD). In South Africa, recently published work based on an investigation of 14 childhood environmental exposures during 3 age intervals (0-5, 6-10 and 11-18 years) has provided insight into the role of timing of exposure in the future development of CD. The 'overlapping' contribution of the investigated variables however, remains unclear. The aim of this study was to perform a post hoc analysis using this data and investigate the extent to which each variable contributes to the subsequent development of CD relative to each aforementioned age interval, based on a score analysis approach.

methodsThree methods were used for the score analysis. Two methods employed the subgrouping of one or more (similar) variables (methods A and B), with each subgroup assigned a score value weighting equal to one. For comparison, the third approach (method 0) involved no grouping of the 14 variables. Thus, each variable held a score value of one.

resultsResults of the score analysis (Method 0) for the environmental exposures during 3 age intervals (0-5, 6-10 and 11-18 years) revealed no significant difference between the case and control groups. By contrast, results from Method A and Method B revealed a significant difference during all 3 age intervals between the case and control groups, with cases having significantly lower exposure scores (approximately 30% and 40% lower, respectively).

conclusionResults from the score analysis provide insight into the 'compound' effects from multiple environmental exposures in the aetiology of CD.

Indexed as

Environmental ExposureAdolescentAge FactorsCase-Control StudiesChildChild, PreschoolCrohn DiseaseFemaleHumansInfantInfant, NewbornMaleRisk FactorsSouth Africa

Identifiers

PMID28170439
PMCPMC5295693
OpenAlexW2586938135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.