ArticlePloS one2017
Comparative study on the in vitro effects of Pseudomonas aeruginosa and seaweed alginates on human gut microbiota.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Prebiotic and Functional Fibers from Micro- and Macroalgae: Gut Microbiota Modulation, Health Benefits, and Food Applications.International journal of molecular sciences · 2025Review
- Selective Utilization of Polyguluronate by the Human GutMarine drugs · 2025Article
- Reversible Stiffening of Biopolymeric Hybrid Networks by Dynamically Switching Cross-LinksACS applied materials & interfaces · 2025Article
- A Horizontally Transferred Alginate Metabolism Gene Cluster in the Human Gut GenusJournal of applied glycoscience · 2025Article
- Article
- Glycerol-derived reuterin regulates human intestinal microbiota and metabolites.Frontiers in microbiology · 2024Article
- Non-Digestible Carbohydrates: Green Extraction from Food By-Products and Assessment of Their Effect on Microbiota Modulation.Nutrients · 2023Review
- Review
- Promising substitute of inconsistent algal alginates: exploring the biocompatible properties of di-O-acetylated, poly-L-guluronate-deficient alginate from soil bacteriumBiotechnologia · 2023Article
- Digestive Characteristics ofFrontiers in nutrition · 2022Article
- 2'-Fucosyllactose Increases the Abundance ofFrontiers in microbiology · 2022Article
- Seaweed Components as Potential Modulators of the Gut Microbiota.Marine drugs · 2021Review
- The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis.Frontiers in microbiology · 2021Review
- Recent progress on engineering microbial alginate lyases towards their versatile role in biotechnological applications.Folia microbiologica · 2020Review
- Effects of a polysaccharide-rich extract derived from Irish-sourced Laminaria digitata on the composition and metabolic activity of the human gut microbiota using an in vitro colonic model.European journal of nutrition · 2020Article
- The Pros and Cons of Using Algal Polysaccharides as Prebiotics.Frontiers in nutrition · 2020Review
- Structural and functional aspects of mannuronic acid-specific PL6 alginate lyase from the human gut microbeThe Journal of biological chemistry · 2019Article
- Prebiotics from Seaweeds: An Ocean of Opportunity?Marine drugs · 2019Review
- Risks and benefits of consuming edible seaweeds.Nutrition reviews · 2019Review
- Bioavailability of Isothiocyanates From Broccoli Sprouts in Protein, Lipid, and Fiber Gels.Molecular nutrition & food research · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Alginates pertain to organic polysaccharides that have been extensively used in food- and medicine-related industries. The present study obtained alginates from an alginate overproducing Pseudomonas aeruginosa PAO1 mutant by screening transposon mutagenesis libraries. The interaction between bacterial and seaweed alginates and gut microbiota were further studied by using an in vitro batch fermentation system. Thin-layer chromatography (TLC) analysis indicated that both bacterial and seaweed alginates can be completely degraded by fecal bacteria isolated from study volunteers, indicating that a minor structural difference between bacterial and seaweed alginates (O-acetylation and lack of G-G blocks) didn't affect the digestion of alginates by human microbiota. Although, the digestion of bacterial and seaweed alginates was attributed to different Bacteroides xylanisolvens strains, they harbored similar alginate lyase genes. Genus Bacteroides with alginate-degrading capability were enriched in growth medium containing bacterial or seaweed alginates after in vitro fermentation. Short-chain fatty acid (SCFA) production in both bacterial and seaweed alginates was also comparable, but was significantly higher than the same medium using starch. In summary, the present study has isolated an alginate-overproducing P. aeruginosa mutant strain. Both seaweed and bacterial alginates were degraded by human gut microbiota, and their regulatory function on gut microbiota was similar.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.