Evidence map›Paper›PMID 28170305›Full record

ArticleAIDS patient care and STDs2017

Impact of Depression and Anxiety on Initiation of Antiretroviral Therapy Among Men Who Have Sex with Men with Newly Diagnosed HIV Infections in China.

Jun Tao, Sten H Vermund, Hongyan Lu, Yuhua Ruan, Bryan E Shepherd, Aaron M Kipp, K Rivet Amico, Xiangjun Zhang, Yiming Shao, Han-Zhu Qian

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In one paragraph

Article in AIDS patient care and STDs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jun Tao1 Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine , Nashville, Tennessee.
Sten H Vermund1 Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine , Nashville, Tennessee.
Hongyan Lu4 Beijing Center for Disease Control and Prevention , Beijing, China .
Yuhua Ruan5 State Key Laboratory of Infectious Disease Prevention and Control (SKLID), Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention (China CDC) , Beijing, China .
Bryan E Shepherd6 Department of Biostatistics, Vanderbilt University School of Medicine , Nashville, Tennessee.
Aaron M Kipp1 Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine , Nashville, Tennessee.
K Rivet Amico7 Department of Health Behavior and Health Education, University of Michigan , Ann Arbor, Michigan.
Xiangjun Zhang8 Xicheng District Center for Disease Control and Prevention , Beijing, China .
Yiming Shao5 State Key Laboratory of Infectious Disease Prevention and Control (SKLID), Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention (China CDC) , Beijing, China .
Han-Zhu Qian1 Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine , Nashville, Tennessee.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression and anxiety are common among persons recently diagnosed with HIV infection. We examined whether depression or anxiety was associated with delayed initiation of antiretroviral therapy (ART) among a prospective cohort of Chinese men who have sex with men (MSM) who were newly diagnosed with HIV. The Hospital Anxiety and Depression Scale (HADS) was used for measuring depression and anxiety, with scores of 0-7, 8-10, and 11-21 representing normal, borderline, and likely, respectively. ART initiation information was extracted from the National ART Database. Cox regression was performed to assess associations between HADS scores and the time to ART initiation. Of 364 eligible participants enrolling in the cohort within a median of 11 days after HIV diagnosis, 62% initiated ART during the 12-month follow-up period. The baseline prevalence for likely/borderline depression was 36%, and likely/borderline anxiety was 42%. In adjusted analyses, compared with a depression score of 0, the likelihood of starting ART was 1.82 [95% confidence interval (CI): 1.38-2.41], 3.11 (95% CI: 1.82-5.30), and 2.53 (95% CI: 1.48-4.32) times higher for depression scores of 3, 9, and 13, respectively. A similar pattern was observed for the anxiety score. In contrast to our hypothesis, both depression and anxiety were associated with earlier ART initiation among Chinese MSM with newly diagnosed HIV. We speculate that individuals who are more concerned about their new HIV diagnosis may be more likely to seek HIV care and follow a doctor's advice. The effects of depression or anxiety on ART initiation likely differ in varying subgroups and by symptom severity.

Indexed as

AdultAntiretroviral Therapy, Highly ActiveAnxietyCD4 Lymphocyte CountChinaDepressionFemaleHIV InfectionsHomosexuality, MaleHumansMalePrevalenceProspective StudiesPsychiatric Status Rating ScalesSocioeconomic Factorsantiretroviral therapyanxietyChinadepressionmen who have sex with mennewly diagnosed HIV infections

Identifiers

PMID28170305
PMCPMC5312604

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.