Evidence map›Paper›PMID 28170196›Full record

ArticleStem cells translational medicine2017

Lacrimal Gland Repair Using Progenitor Cells.

Anastasia Gromova, Dmitry A Voronov, Miya Yoshida, Suharika Thotakura, Robyn Meech, Darlene A Dartt, Helen P Makarenkova

Open access · goldAbstract read
In one paragraph

Article in Stem cells translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Tissue Engineering and Ophthalmology.Turkish journal of ophthalmology · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Alternative therapies for dry eye disease.Current opinion in ophthalmology · 2021
    Review
  13. Review
  14. Mouse Models of Sjögren's Syndrome with Ocular Surface Disease.International journal of molecular sciences · 2020
    Review
  15. Functions of the plasminogen receptor Plg-RJournal of thrombosis and haemostasis : JTH · 2020
    Review
  16. Article
  17. Article
  18. Article
  19. The plasminogen receptorJournal of thrombosis and haemostasis : JTH · 2018
    Article
  20. Establishing and characterizing lacrispheres from human lacrimal gland for potential clinical application.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Anastasia GromovaDepartment of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
Dmitry A VoronovDepartment of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
Miya YoshidaDepartment of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
Suharika ThotakuraDepartment of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
Robyn MeechDepartment of Clinical Pharmacology, Flinders University, Bedford Park, South Australia, Australia.
Darlene A DarttDepartment of Ophthalmology Harvard Medical School, Schepens Eye Research Institute/Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
Helen P MakarenkovaDepartment of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
Scripps Research Institute · USFlinders University · AUInstitute for Information Transmission Problems · RUSmith-Kettlewell Eye Research Institute · USUniversity of California, San Diego · US

Funding

Lacrimal Gland Repair Using Progenitor CellsR01EY026202 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2016 to 2025
$5.2M
Regulation of lacrimal gland development and regenerationR21EY021292 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2011 to 2012
$475k
NEI NIH HHS R01 EY026202NEI NIH HHS R21 EY021292
6 · The paper itself

Abstract

In humans, the lacrimal gland (LG) is the primary contributor to the aqueous layer of the tear film. Production of tears in insufficient quantity or of inadequate quality may lead to aqueous-deficiency dry eye (ADDE). Currently there is no cure for ADDE. The development of strategies to reliably isolate LG stem/progenitor cells from the LG tissue brings great promise for the design of cell replacement therapies for patients with ADDE. We analyzed the therapeutic potential of epithelial progenitor cells (EPCPs) isolated from adult wild-type mouse LGs by transplanting them into the LGs of TSP -1

Indexed as

RegenerationAnimalsCell DifferentiationColony-Forming Units AssayEpithelial Cell Adhesion MoleculeEpithelial CellsLacrimal ApparatusMice, Inbred C57BLProto-Oncogene Proteins c-kitStem CellsStem Cell TransplantationTranscription FactorsEpithelial Cell Adhesion MoleculeProto-Oncogene Proteins c-kitTranscription FactorsCell cultureCell surface markersCell transplantationCellular therapyc-kitFluorescence-activated cell sortingGene expressionTissue-specific stem cells

Identifiers

PMID28170196
PMCPMC5442743
OpenAlexW2512503977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.