ArticleNature communications2017
Clustering of 770,000 genomes reveals post-colonial population structure of North America.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Prospective Analysis of Genetic Variants Associated with Human Lifespan.G3 (Bethesda, Md.) · 2019Pooled it
- Genetic European Ancestry and Incident Diabetes in Black Individuals: Insights From the SPRINT Trial.Circulation. Genomic and precision medicine · 2022Trial
- RaPID2: a parallel scalable framework for identity-by-descent segment detection via parallel PBWT.Bioinformatics advances · 2026Article
- Genetics and context for precision health in Greater Boston.Nature communications · 2025Article
- clusIBD: Robust Detection of Identity-by-descent Segments Using Unphased Genetic Data from Poor-quality Samples.Genomics, proteomics & bioinformatics · 2025Article
- Genetic disease risks of under-represented founder populations in New York City.PLoS genetics · 2025Article
- Genetic ancestry and population structure in the All of Us Research Program cohort.Nature communications · 2025Article
- The genetic footprint of the European Roma diaspora: evidence from the Balkans to the Iberian Peninsula.Human genetics · 2025Article
- Overview of Alzheimer's Disease Neuroimaging Initiative and future clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Understanding the genomic heterogeneity of North African Imazighen: from broad to microgeographical perspectives.Scientific reports · 2024Article
- Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum.Nature communications · 2024Article
- Accurate detection of identity-by-descent segments in human ancient DNA.Nature genetics · 2024Article
- Decoding Genetics, Ancestry, and Geospatial Context for Precision Health.medRxiv : the preprint server for health sciences · 2023Article
- Article
- Strong Positive Selection Biases Identity-By-Descent-Based Inferences of Recent Demography and Population Structure inbioRxiv : the preprint server for biology · 2023Article
- The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago.Communications biology · 2023Article
- Regional Variation in Hormonal and Metabolic Parameters of White and Black Women With PCOS in the United States.The Journal of clinical endocrinology and metabolism · 2023Article
- Genomic Insights into the Population History of the Resande or Swedish Travelers.Genome biology and evolution · 2023Article
- The impact of modern admixture on archaic human ancestry in human populations.bioRxiv : the preprint server for biology · 2023Article
- Selecting Clustering Algorithms for Identity-By-Descent Mapping.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2023Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite strides in characterizing human history from genetic polymorphism data, progress in identifying genetic signatures of recent demography has been limited. Here we identify very recent fine-scale population structure in North America from a network of over 500 million genetic (identity-by-descent, IBD) connections among 770,000 genotyped individuals of US origin. We detect densely connected clusters within the network and annotate these clusters using a database of over 20 million genealogical records. Recent population patterns captured by IBD clustering include immigrants such as Scandinavians and French Canadians; groups with continental admixture such as Puerto Ricans; settlers such as the Amish and Appalachians who experienced geographic or cultural isolation; and broad historical trends, including reduced north-south gene flow. Our results yield a detailed historical portrait of North America after European settlement and support substantial genetic heterogeneity in the United States beyond that uncovered by previous studies.
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